Difference between revisions of "Spo0A"

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|style="background:#ABCDEF;" align="center"|'''Function''' || initiation of sporulation
 
|style="background:#ABCDEF;" align="center"|'''Function''' || initiation of sporulation
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/Spo0A Spo0A]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/biofilm.html Biofilm], [http://subtiwiki.uni-goettingen.de/pathways/gene_regulation_nucleotides.html Nucleotides (regulation)], [http://subtiwiki.uni-goettingen.de/pathways/glutamate.html Ammonium/ glutamate], <br/>[http://subtiwiki.uni-goettingen.de/pathways/carbon_flow.html Central C-metabolism],[http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism], [http://subtiwiki.uni-goettingen.de/pathways/phosphorelay.html Phosphorelay], [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress], <br/>[http://subtiwiki.uni-goettingen.de/pathways/tRNA_charging.html tRNA charging],[http://subtiwiki.uni-goettingen.de/pathways/fatty_acid_synthesis.html Lipid synthesis], [http://subtiwiki.uni-goettingen.de/wiki/index.php/Protein_secretion Protein secretion] '''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/biofilm.html Biofilm], [http://subtiwiki.uni-goettingen.de/pathways/gene_regulation_nucleotides.html Nucleotides (regulation)], [http://subtiwiki.uni-goettingen.de/pathways/glutamate.html Ammonium/ glutamate], <br/>[http://subtiwiki.uni-goettingen.de/pathways/carbon_flow.html Central C-metabolism],[http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism], [http://subtiwiki.uni-goettingen.de/pathways/phosphorelay.html Phosphorelay], [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress], <br/>[http://subtiwiki.uni-goettingen.de/pathways/tRNA_charging.html tRNA charging],[http://subtiwiki.uni-goettingen.de/pathways/fatty_acid_synthesis.html Lipid synthesis], [http://subtiwiki.uni-goettingen.de/wiki/index.php/Protein_secretion Protein secretion] '''

Revision as of 21:05, 21 July 2011

  • Description: phosphorelay regulator, initiation of sporulation

Gene name spo0A
Synonyms spo0C, spo0G, spoIIL, sof-1
Essential no
Product phosphorelay response regulator
Function initiation of sporulation
Interactions involving this protein in SubtInteract: Spo0A
Metabolic function and regulation of this protein in SubtiPathways:
Biofilm, Nucleotides (regulation), Ammonium/ glutamate,
Central C-metabolism,Sugar catabolism, Phosphorelay, Stress,
tRNA charging,Lipid synthesis, Protein secretion
MW, pI 29 kDa, 5.989
Gene length, protein length 801 bp, 267 aa
Immediate neighbours yqiG, spoIVB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Spo0A context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

transcription factors and their control, phosphorelay, phosphoproteins

This gene is a member of the following regulons

SigH regulon, Spo0A regulon

The Spo0A regulon

The gene

Basic information

  • Locus tag: BSU24220

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: receives phosphorylation from Spo0B, dephosphorylation by Spo0E, direct phosphorylation by KinC upon potassium leakage PubMed
  • Cofactor(s):
  • Effectors of protein activity:
    • the phosphorylation state affects DNA binding activity
    • interaction with MecA inhibits the transcriptional activity of Spo0A∼P PubMed
  • Localization:

Database entries

  • Structure: 1QMP (with phosphorylated aspartate, Geobacillus stearothermophilus), 1FC3 (trans-activation domain, Geobacillus stearothermophilus), 1LQ1 (complex with DNA)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
    • repressed by casamino acids PubMed
    • repressed by SinR overexpression PubMed
    • repressed by soj PubMed
    • expression increases when drowth rate declines PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

The Spo0A regulon

Other original Publications

Additonal publications: PubMed

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