Difference between revisions of "Fur"
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and transcription of ferri-siderophore uptake genes | and transcription of ferri-siderophore uptake genes | ||
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− | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://cellpublisher.gobics.de/view/GqbblRJkBH | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://cellpublisher.gobics.de/view/GqbblRJkBH Metal ion homeostasis], [http://subtiwiki.uni-goettingen.de/pathways/other_nitrogen_sources/index.html Alternative nitrogen sources], [http://subtiwiki.uni-goettingen.de/wiki/index.php/Protein_secretion Protein secretion]''' |
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 17 kDa, 5.374 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 17 kDa, 5.374 |
Revision as of 13:06, 11 March 2011
- Description: transcription regulator of iron homoeostasis
Gene name | fur |
Synonyms | yqkL |
Essential | no |
Product | transcriptional repressor |
Function | regulation of iron homoeostasis
and transcription of ferri-siderophore uptake genes |
Metabolic function and regulation of this protein in SubtiPathways: Metal ion homeostasis, Alternative nitrogen sources, Protein secretion | |
MW, pI | 17 kDa, 5.374 |
Gene length, protein length | 447 bp, 149 aa |
Immediate neighbours | ripX, spoIIM |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
|
Contents
Categories containing this gene/protein
acquisition of iron, iron metabolism, transcription factors and their control
This gene is a member of the following regulons
The Fur regulon
The gene
Basic information
- Locus tag: BSU23520
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: Fur family (according to Swiss-Prot)
Genes controlled by Fur
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s): contains an iron-sulfur cluster
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P54574
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: fur PubMed
- Additional information:
Biological materials
- Mutant: HB6543 (aphA3), available in the John Helmann lab; also available in the Stülke lab GP879 (fur::mls) and GP868 (fur::mls, perR::spc)
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
Your additional remarks
References
The Fur regulon
Noel Baichoo, John D Helmann
Recognition of DNA by Fur: a reinterpretation of the Fur box consensus sequence.
J Bacteriol: 2002, 184(21);5826-32
[PubMed:12374814]
[WorldCat.org]
[DOI]
(P p)
Noel Baichoo, Tao Wang, Rick Ye, John D Helmann
Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon.
Mol Microbiol: 2002, 45(6);1613-29
[PubMed:12354229]
[WorldCat.org]
[DOI]
(P p)
Other original publications