Difference between revisions of "Spo0A"
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| Line 80: | Line 80: | ||
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
| − | * '''Effectors of protein activity:''' the phosphorylation state affects DNA binding activity | + | * '''Effectors of protein activity:''' |
| + | ** the phosphorylation state affects DNA binding activity | ||
| + | ** interaction with [[MecA]] inhibits the transcriptional activity of [[Spo0A]]∼P {{PubMed|21435029}} | ||
| − | * '''Interactions:''' [[KinC]]-[[Spo0A]] {{PubMed|19114652}} | + | * '''Interactions:''' |
| + | ** [[KinC]]-[[Spo0A]] {{PubMed|19114652}} | ||
| + | ** [[Spo0A]]-[[Spo0E]] {{PubMed|12067336}} | ||
| + | ** [[Spo0A]]-[[SigA]] {{PubMed|14976210}} | ||
| + | ** [[Spo0A]]-[[Spo0B]] | ||
| + | ** [[SinI]]-[[Spo0A]] {{PubMed|21326214}} | ||
| + | ** [[MecA]]-[[Spo0A]] {{PubMed|21435029}} | ||
* '''Localization:''' | * '''Localization:''' | ||
| Line 141: | Line 149: | ||
<pubmed>14651647,15687200, </pubmed> | <pubmed>14651647,15687200, </pubmed> | ||
==Other original Publications== | ==Other original Publications== | ||
| − | '''Additonal publications:''' {{PubMed|21326214}} | + | '''Additonal publications:''' {{PubMed|21326214,21435029}} |
<pubmed>14679239, 1569009 20413551 20404177 19528067, 19581368 , 8730857,2106683,3157992, 11254139, 12067336, 10869437, 16385044,9287005, 8127878,9287022, 8231806, 1905258,16452424,2118505,8207022, 12176382, 9733708, 11069677,1391039,12730135, 2437099,8288522,16166384,9495766,2118512,1556084, 18296515,7768874, 3145384, 19114652 20689749 1537790,9658000, 8509330,14762002, 1846779, 2981817, 9477965,8600030, 18840696, 1391039, 14976210, 19207565 11679073 12270811 11112444 18978066 20154131 14712656 17157871 15060025 </pubmed> | <pubmed>14679239, 1569009 20413551 20404177 19528067, 19581368 , 8730857,2106683,3157992, 11254139, 12067336, 10869437, 16385044,9287005, 8127878,9287022, 8231806, 1905258,16452424,2118505,8207022, 12176382, 9733708, 11069677,1391039,12730135, 2437099,8288522,16166384,9495766,2118512,1556084, 18296515,7768874, 3145384, 19114652 20689749 1537790,9658000, 8509330,14762002, 1846779, 2981817, 9477965,8600030, 18840696, 1391039, 14976210, 19207565 11679073 12270811 11112444 18978066 20154131 14712656 17157871 15060025 </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 07:51, 26 March 2011
- Description: phosphorelay regulator, initiation of sporulation
| Gene name | spo0A |
| Synonyms | spo0C, spo0G, spoIIL, sof-1 |
| Essential | no |
| Product | phosphorelay response regulator |
| Function | initiation of sporulation |
| Metabolic function and regulation of this protein in SubtiPathways: Biofilm, Nucleotides (regulation), Ammonium/ glutamate, Central C-metabolism,Sugar catabolism, Phosphorelay, Stress, tRNA charging,Lipid synthesis, Protein secretion | |
| MW, pI | 29 kDa, 5.989 |
| Gene length, protein length | 801 bp, 267 aa |
| Immediate neighbours | yqiG, spoIVB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
transcription factors and their control, phosphorelay, phosphoproteins
This gene is a member of the following regulons
The Spo0A regulon
The gene
Basic information
- Locus tag: BSU24220
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: receives phosphorylation from Spo0B, dephosphorylation by Spo0E, direct phosphorylation by KinC upon potassium leakage PubMed
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure: 1QMP (with phosphorylated aspartate, Geobacillus stearothermophilus), 1FC3 (trans-activation domain, Geobacillus stearothermophilus), 1LQ1 (complex with DNA)
- UniProt: P06534
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: spo0A PubMed
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
- Tony Wilkinson, York University, U.K. homepage
- Imrich Barak, Slovak Academy of Science, Bratislava, Slovakia homepage
- Charles Moran, Emory University, NC, USA homepage
Your additional remarks
References
Reviews
José Eduardo González-Pastor
Cannibalism: a social behavior in sporulating Bacillus subtilis.
FEMS Microbiol Rev: 2011, 35(3);415-24
[PubMed:20955377]
[WorldCat.org]
[DOI]
(I p)
Michiel J L de Hoon, Patrick Eichenberger, Dennis Vitkup
Hierarchical evolution of the bacterial sporulation network.
Curr Biol: 2010, 20(17);R735-45
[PubMed:20833318]
[WorldCat.org]
[DOI]
(I p)
Tsutomu Katayama, Shogo Ozaki, Kenji Keyamura, Kazuyuki Fujimitsu
Regulation of the replication cycle: conserved and diverse regulatory systems for DnaA and oriC.
Nat Rev Microbiol: 2010, 8(3);163-70
[PubMed:20157337]
[WorldCat.org]
[DOI]
(I p)
Daniel López, Roberto Kolter
Extracellular signals that define distinct and coexisting cell fates in Bacillus subtilis.
FEMS Microbiol Rev: 2010, 34(2);134-49
[PubMed:20030732]
[WorldCat.org]
[DOI]
(I p)
Daniel Schultz, Peter G Wolynes, Eshel Ben Jacob, José N Onuchic
Deciding fate in adverse times: sporulation and competence in Bacillus subtilis.
Proc Natl Acad Sci U S A: 2009, 106(50);21027-34
[PubMed:19995980]
[WorldCat.org]
[DOI]
(I p)
S Seredick, G B Spiegelman
Lessons and questions from the structure of the Spo0A activation domain.
Trends Microbiol: 2001, 9(4);148-51
[PubMed:11286862]
[WorldCat.org]
[DOI]
(P p)
The Spo0A regulon
Other original Publications
Additonal publications: PubMed
