Difference between revisions of "Mta"

From SubtiWiki
Jump to: navigation, search
(Extended information on the protein)
Line 79: Line 79:
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
  
* '''Interactions:'''
+
* '''[[SubtInteract|Interactions]]:'''
  
* '''Localization:''' cytoplasm (according to Swiss-Prot)
+
* '''[[Localization]]:''' cytoplasm (according to Swiss-Prot)
  
 
=== Database entries ===
 
=== Database entries ===

Revision as of 18:10, 2 December 2011

  • Description: transcriptional activator of multidrug-efflux transporter genes, activates ymfD expression

Gene name mta
Synonyms ywnD
Essential no
Product transcriptional activator
Function regulation of multidrug-efflux transporter genes
MW, pI 29 kDa, 4.949
Gene length, protein length 771 bp, 257 aa
Immediate neighbours clsA, ywnC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Mta context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

transcription factors and their control, resistance against toxins/ antibiotics

This gene is a member of the following regulons

Mta regulon

The Mta regulon

The gene

Basic information

  • Locus tag: BSU36600

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1JBG (N-terminal domain), 1R8D (complex of N-terminal domain with DNA)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • positive autoregulation PubMed
  • Regulatory mechanism:
    • Mta: transcription activation PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Mohamed Marahiel, Marburg University, Germany homepage

Richard Brennan, Houston, Texas, USA Homepage

Your additional remarks

References

Marcus Miethke, Sarah Schmidt, Mohamed A Marahiel
The major facilitator superfamily-type transporter YmfE and the multidrug-efflux activator Mta mediate bacillibactin secretion in Bacillus subtilis.
J Bacteriol: 2008, 190(15);5143-52
[PubMed:18502870] [WorldCat.org] [DOI] (I p)

Kate J Newberry, Richard G Brennan
The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus.
J Biol Chem: 2004, 279(19);20356-62
[PubMed:14985361] [WorldCat.org] [DOI] (P p)

M H Godsey, N N Baranova, A A Neyfakh, R G Brennan
Crystal structure of MtaN, a global multidrug transporter gene activator.
J Biol Chem: 2001, 276(50);47178-84
[PubMed:11581256] [WorldCat.org] [DOI] (P p)

M H Godsey, N N Baranova, A A Neyfakh, R G Brennan
Crystallization and preliminary X-ray diffraction studies on the DNA-binding domain of the multidrug transporter activation protein (MtaN) from Bacillus subtilis.
Acta Crystallogr D Biol Crystallogr: 2000, 56(Pt 11);1456-8
[PubMed:11053850] [WorldCat.org] [DOI] (P p)

N N Baranova, A Danchin, A A Neyfakh
Mta, a global MerR-type regulator of the Bacillus subtilis multidrug-efflux transporters.
Mol Microbiol: 1999, 31(5);1549-59
[PubMed:10200972] [WorldCat.org] [DOI] (P p)

E Presecan, I Moszer, L Boursier, H Cruz Ramos, V de la Fuente, M-F Hullo, C Lelong, S Schleich, A Sekowska, B H Song, G Villani, F Kunst, A Danchin, P Glaser
The Bacillus subtilis genome from gerBC (311 degrees) to licR (334 degrees).
Microbiology (Reading): 1997, 143 ( Pt 10);3313-3328
[PubMed:9353933] [WorldCat.org] [DOI] (P p)