Difference between revisions of "DegS"
Line 78: | Line 78: | ||
** aa 289 ... 384: HATPase_c | ** aa 289 ... 384: HATPase_c | ||
− | * '''Modification:''' phosphorylation on Ser-76 [http://www.ncbi.nlm.nih.gov/sites/entrez/17218307 PubMed], autophosphorylation on His-189 | + | * '''Modification:''' |
+ | ** phosphorylation on Ser-76 [http://www.ncbi.nlm.nih.gov/sites/entrez/17218307 PubMed], this stimulates phosphotransfer from His-189 to [[DegU]] {{PubMed|21304896}}, the phosphorylyation is performed by [[PrkD]] ''in vitro'' {{PubMed|21304896}} | ||
+ | ** autophosphorylation on His-189 | ||
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
Line 134: | Line 136: | ||
=References= | =References= | ||
− | <pubmed>17850253,12471443,14563871,1459944,1901568,10094672,1688843 ,16479537, 17218307 </pubmed> | + | <pubmed>17850253,12471443,14563871,1459944,1901568,10094672,1688843 ,16479537, 17218307 21304896 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] |
Revision as of 13:43, 12 February 2011
- Description: two-component sensor kinase for exoenzyme and competence regulation
Gene name | degS |
Synonyms | sacU |
Essential | no |
Product | two-component sensor kinase |
Function | regulation of degradative enzyme and genetic competence |
MW, pI | 44 kDa, 5.988 |
Gene length, protein length | 1155 bp, 385 aa |
Immediate neighbours | degU, yvyE |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
|
Contents
Categories containing this gene/protein
protein modification, transcription factors and their control, phosphoproteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU35500
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: autophosphorylation, autodephosphorylation, phosphorylation of DegU on Asp-56 PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- aa 12 ... 170: unknown DegS domain
- aa 180 ... 248: HisKA_3 domain (autophosphorylation)
- aa 289 ... 384: HATPase_c
- Modification:
- Cofactor(s):
- Effectors of protein activity: DegQ (stimulation of autophosphorylation)
- Localization: Cytoplasm (Homogeneous) PubMed
Database entries
- Structure:
- UniProt: P13799
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Tarek Msadek, Institut Pasteur, Paris, France
Your additional remarks
References