Difference between revisions of "CymR"
| Line 39: | Line 39: | ||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
{{SubtiWiki regulon|[[stringent response]]}} | {{SubtiWiki regulon|[[stringent response]]}} | ||
| − | + | =The [[CymR regulon]]= | |
=The gene= | =The gene= | ||
| Line 136: | Line 136: | ||
=References= | =References= | ||
| − | + | ==The [[CymR regulon]]== | |
| − | <pubmed>18974048,17056751,16109943,16885442 11948165 | + | <pubmed>16513748, </pubmed> |
| + | ==Other original publications== | ||
| + | <pubmed>18974048,17056751,16109943,16885442 11948165 , 15668000 20608979 </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 10:49, 12 December 2010
- Description: pleiotropic regulator of sulphur metabolism
| Gene name | cymR |
| Synonyms | yrzC |
| Essential | no |
| Product | transcription repressor |
| Function | regulation of sulphur metabolism |
| Metabolic function and regulation of this protein in SubtiPathways: Riboflavin / FAD, Cys, Met & Sulfate assimilation | |
| MW, pI | 11 kDa, 9.879 |
| Gene length, protein length | 333 bp, 111 aa |
| Immediate neighbours | yrvO, yrvN |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
sulfur metabolism, regulators of core metabolism
This gene is a member of the following regulons
The CymR regulon
The gene
Basic information
- Locus tag: BSU27520
Phenotypes of a mutant
- impaired growth in the presence of cystine and increased sensitivity to hydrogen peroxide-, disulfide-, paraquat- and tellurite-induced stresses PubMed
- increased intracellular cysteine pool and hydrogen sulfide formation PubMed
- depletion of branched-chain amino acids PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: Rrf2 family of transcription regulators
- Paralogous protein(s):
Genes repressed by CymR
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Effectors of protein activity:
- Interactions: CymR-CysK, the complex is formed in the presence of cysteine, and results in DNA binding and repression of genes of cysteine biosynthesis PubMed
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: O34527
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Isabelle Martin-Verstraete, Institute Pasteur, Paris, France
Your additional remarks
References
The CymR regulon
Other original publications
