Difference between revisions of "SpeA"
(→References) |
|||
| Line 1: | Line 1: | ||
| − | * '''Description:''' arginine decarboxylase <br/><br/> | + | * '''Description:''' arginine decarboxylase, required for [[biofilm formation]] <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
| Line 40: | Line 40: | ||
===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| + | * no [[biofilm formation]] {{PubMed|20876533}} | ||
=== Database entries === | === Database entries === | ||
| Line 120: | Line 121: | ||
=References= | =References= | ||
| − | <pubmed> 19255484 9723923 </pubmed> | + | <pubmed> 19255484 9723923 20876533 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 08:44, 30 September 2010
- Description: arginine decarboxylase, required for biofilm formation
| Gene name | speA |
| Synonyms | cad |
| Essential | no |
| Product | arginine decarboxylase |
| Function | spermidine, polyamine biosynthesis |
| Metabolic function and regulation of this protein in SubtiPathways: Cys, Met & Sulfate assimilation | |
| MW, pI | 53 kDa, 5.081 |
| Gene length, protein length | 1470 bp, 490 aa |
| Immediate neighbours | sr1, yktA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU14630
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: L-arginine = agmatine + CO2 (according to Swiss-Prot)
- Protein family: Orn/Lys/Arg decarboxylase class-I family (according to Swiss-Prot)
- Paralogous protein(s): YaaO
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P21885
- KEGG entry: [2]
- E.C. number: 4.1.1.19
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Matthew Burrell, Colin C Hanfrey, Ewan J Murray, Nicola R Stanley-Wall, Anthony J Michael
Evolution and multiplicity of arginine decarboxylases in polyamine biosynthesis and essential role in Bacillus subtilis biofilm formation.
J Biol Chem: 2010, 285(50);39224-38
[PubMed:20876533]
[WorldCat.org]
[DOI]
(I p)
Xiao Yan Liu, Jian Lei, Xiang Liu, Xiao Dong Su, Lanfen Li
Preliminary X-ray crystallographic studies of Bacillus subtilis SpeA protein.
Acta Crystallogr Sect F Struct Biol Cryst Commun: 2009, 65(Pt 3);282-4
[PubMed:19255484]
[WorldCat.org]
[DOI]
(I p)
A Sekowska, P Bertin, A Danchin
Characterization of polyamine synthesis pathway in Bacillus subtilis 168.
Mol Microbiol: 1998, 29(3);851-8
[PubMed:9723923]
[WorldCat.org]
[DOI]
(P p)
