Difference between revisions of "SigD"
(→Expression and regulation) |
|||
| Line 71: | Line 71: | ||
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
| − | * '''Effectors of protein activity:''' | + | * '''Effectors of protein activity:''' interaction with [[FlgM]] inhibits SigD activity {{PubMed|10207036}} |
| − | * '''Interactions:''' [[SigD]]-[[FlgM]] | + | * '''Interactions:''' [[SigD]]-[[FlgM]] {{PubMed|10207036}} |
* '''Localization:''' | * '''Localization:''' | ||
| Line 105: | Line 105: | ||
** [[Spo0A]]: transcription repression {{PubMed|14651647}} | ** [[Spo0A]]: transcription repression {{PubMed|14651647}} | ||
** [[CodY]]: transcription repression {{PubMed|12730172}} | ** [[CodY]]: transcription repression {{PubMed|12730172}} | ||
| + | ** [[DegU]] (non-phosphorylated): transcription activation {{PubMed|17850253}} | ||
* '''Additional information:''' | * '''Additional information:''' | ||
| Line 130: | Line 131: | ||
<pubmed> 20233302 </pubmed> | <pubmed> 20233302 </pubmed> | ||
==Original publications== | ==Original publications== | ||
| − | <pubmed>8955328,7708689,15033535,9648743,8169223,9096206,15175317,2498284,16357223,3127378,9144176,18820022,2111808,7602586,2832368,8195064,11987133,,14651647, 9335309 9657996,8157612,15175317 10809682 8932324 20233303 </pubmed> | + | <pubmed>8955328,7708689,15033535,9648743,8169223,9096206,15175317,2498284,16357223,3127378,9144176,18820022,2111808,7602586,2832368,8195064,11987133,,14651647, 9335309 9657996,8157612,15175317 10809682 8932324 20233303 17850253 10207036 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 18:31, 31 July 2010
- Description: RNA polymerase sigma factor SigD
| Gene name | sigD |
| Synonyms | flaB |
| Essential | no |
| Product | RNA polymerase sigma factor SigD |
| Function | regulation of flagella, motility, chemotaxis and autolysis |
| MW, pI | 29 kDa, 5.167 |
| Gene length, protein length | 762 bp, 254 aa |
| Immediate neighbours | cheD, swrB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU16470
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: sigma-70 factor family (according to Swiss-Prot)
- Paralogous protein(s):
Genes/ operons controlled by SigD
dltA-dltB-dltC-dltD-dltE, cheV, degR, epr, hag, lytA-lytB-lytC, lytD, lytF, tlpA-mcpA, mcpB, mcpC, motA-motB, nfrA-ywcH
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Localization:
Database entries
- Structure:
- UniProt: P10726
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- flgB-flgC-fliE-fliF-fliG-fliH-fliI-fliJ-ylxF-fliK-ylxG-flgE-fliL-fliM-fliY-cheY-fliZ-fliP-fliQ-fliR-flhB-flhA-flhF-ylxH-cheB-cheA-cheW-cheC-cheD-sigD-swrB PubMed
- ylxF-fliK-ylxG-flgE-fliL-fliM-fliY-cheY-fliZ-fliP-fliQ-fliR-flhB-flhA-flhF-ylxH-cheB-cheA-cheW-cheC-cheD-sigD-swrB PubMed
- sigD-swrB PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system: B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Stülke lab
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Jan-Willem Veening, Oscar P Kuipers
Gene position within a long transcript as a determinant for stochastic switching in bacteria.
Mol Microbiol: 2010, 76(2);269-72
[PubMed:20233302]
[WorldCat.org]
[DOI]
(I p)
Original publications
