Difference between revisions of "MtlA"

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* '''Description:''' [[trigger enzymes|trigger enzyme]]: mannitol-specific [[PTS|phosphotransferase system]], EIICB of the [[PTS]]<br/><br/>
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* '''Description:''' [[trigger enzymes|trigger enzyme]]: mannitol-specific [[PTS|phosphotransferase system]], EIICB of the [[PTS]]&lt;br/>&lt;br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"|'''Function''' || mannitol uptake and phosphorylation, control of [[MtlR]] activity
 
|style="background:#ABCDEF;" align="center"|'''Function''' || mannitol uptake and phosphorylation, control of [[MtlR]] activity
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism]'''
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: &lt;br/>[http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism]'''
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 65 kDa, 8.778   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 65 kDa, 8.778   
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ycnL]]'', ''[[mtlF]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ycnL]]'', ''[[mtlF]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB12206&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&amp;#91;EMBLCDS:CAB12206&amp;#93;+-newId sequences] &lt;br/> (Barbe ''et al.'', 2009)'''
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:mtlA_context.gif]]
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|colspan="2" | '''Genetic context''' &lt;br/> [[Image:mtlA_context.gif]]
  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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  &lt;div align="right"> &lt;small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]&lt;/small>&lt;/div>
 
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__TOC__
 
__TOC__
  
<br/><br/><br/><br/><br/><br/>
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&lt;br/>&lt;br/>&lt;br/>&lt;br/>&lt;br/>&lt;br/>
  
 
=The gene=
 
=The gene=
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=References=
 
=References=
  
<pubmed>12897001, 20444094, 10627040 , 17218307 </pubmed>
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&lt;pubmed>12897001, 20444094, 10627040 , 17218307 &lt;/pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 23:40, 23 November 2010



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Gene name mtlA
Synonyms
Essential no
Product trigger enzyme: mannitol-specific phosphotransferase system, EIICB
Function mannitol uptake and phosphorylation, control of MtlR activity
Metabolic function and regulation of this protein in SubtiPathways: <br/>Sugar catabolism
MW, pI 65 kDa, 8.778
Gene length, protein length 1830 bp, 610 aa
Immediate neighbours ycnL, mtlF
Get the DNA and protein sequences <br/> (Barbe et al., 2009)
Genetic context <br/> MtlA context.gif
<div align="right"> <small>This image was kindly provided by SubtiList</small></div>

<br/><br/><br/><br/><br/><br/>

The gene

Basic information

  • Locus tag: BSU03981

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine (according to Swiss-Prot)
  • Protein family: PTS permease, fructose/ mannitol permease (Fru) family PubMed
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylation on Ser-559 PubMed
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure: 1A3A (from Escherichia coli k12 mutant, 42% identity, 66% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

<pubmed>12897001, 20444094, 10627040 , 17218307 </pubmed>