Difference between revisions of "CcpA"
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[[Wolfgang Hillen]], Erlangen University, Germany [http://www.astbury.leeds.ac.uk/People/staffpage.php?StaffID=SEVP Homepage] | [[Wolfgang Hillen]], Erlangen University, Germany [http://www.astbury.leeds.ac.uk/People/staffpage.php?StaffID=SEVP Homepage] | ||
| − | [[Richard Brennan]], | + | [[Richard Brennan]], Houston, Texas, USA [http://www.mdanderson.org/departments/biochem/display.cfm?id=556ef368-6c81-4043-b74f350d41dd06cb&method=displayfull&pn=a8427ebd-d0ff-11d4-80fd00508b603a14 Homepage] |
[[Milton H. Saier]], University of California at San Diego, USA [http://www.astbury.leeds.ac.uk/People/staffpage.php?StaffID=SEVP Homepage] | [[Milton H. Saier]], University of California at San Diego, USA [http://www.astbury.leeds.ac.uk/People/staffpage.php?StaffID=SEVP Homepage] | ||
Revision as of 16:46, 9 January 2009
- Description: carbon catabolite control protein A, involved in glucose regulation of many genes; mediates carbon catabolite repression (CCR) of catabolic genes and the positive regulation of genes involved in excretion of excess carbon
| Gene name | ccpA |
| Synonyms | graR, alsA, amyR |
| Essential | no |
| Product | transcriptional regulator |
| Function | mediates carbon catabolite repression (CCR) |
| MW, pI | 36,8 kDa, 5.06 |
| Gene length, protein length | 1002 bp, 334 amino acids |
| Immediate neighbours | aroA, motP |
| Gene sequence (+200bp) | Protein sequence |
| Genetic context File:GenE context.gif | |
Contents
The gene
Basic information
- Coordinates:
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: transcriptional regulator of carbon catabolite repression (CCR)
- Protein family: LacI family
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- HTH lacI-type Domain (1 – 58)
- DNA binding Domain (6 – 25)
- Modification:
- Cofactor(s): HPr-Ser46-P, Crh-Ser-46-P
- Effectors of protein activity:glucose-6-phosphate, fructose-1,6-bisphosphate Pubmed
- Localization:
Database entries
- Swiss prot entry: [3]
- KEGG entry: [4]
- E.C. number:
Additional information
Expression and regulation
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
Labs working on this gene/protein
Wolfgang Hillen, Erlangen University, Germany Homepage
Richard Brennan, Houston, Texas, USA Homepage
Milton H. Saier, University of California at San Diego, USA Homepage
Yasutaro Fujita, Leeds University, USA Homepage
