Difference between revisions of "Mta"
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| − | [[Mohamed | + | [[Mohamed Marahiel]], Marburg University, Germany [http://www.uni-marburg.de/fb15/fachgebiete/bio/marahiel?language_sync=1 homepage] |
[[Richard Brennan]], Houston, Texas, USA [http://www.mdanderson.org/departments/biochem/display.cfm?id=556ef368-6c81-4043-b74f350d41dd06cb&method=displayfull&pn=a8427ebd-d0ff-11d4-80fd00508b603a14 Homepage] | [[Richard Brennan]], Houston, Texas, USA [http://www.mdanderson.org/departments/biochem/display.cfm?id=556ef368-6c81-4043-b74f350d41dd06cb&method=displayfull&pn=a8427ebd-d0ff-11d4-80fd00508b603a14 Homepage] | ||
Revision as of 15:36, 6 January 2010
- Description: transcriptional activator of multidrug-efflux transporter genes, activates ymfD expression
| Gene name | mta |
| Synonyms | ywnD |
| Essential | no |
| Product | transcriptional activator |
| Function | regulation of multidrug-efflux transporter genes |
| MW, pI | 29 kDa, 4.949 |
| Gene length, protein length | 771 bp, 257 aa |
| Immediate neighbours | clsA, ywnC |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU36600
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- UniProt: P71039
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Mohamed Marahiel, Marburg University, Germany homepage
Richard Brennan, Houston, Texas, USA Homepage
Your additional remarks
References
Marcus Miethke, Sarah Schmidt, Mohamed A Marahiel
The major facilitator superfamily-type transporter YmfE and the multidrug-efflux activator Mta mediate bacillibactin secretion in Bacillus subtilis.
J Bacteriol: 2008, 190(15);5143-52
[PubMed:18502870]
[WorldCat.org]
[DOI]
(I p)
Kate J Newberry, Richard G Brennan
The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus.
J Biol Chem: 2004, 279(19);20356-62
[PubMed:14985361]
[WorldCat.org]
[DOI]
(P p)
M H Godsey, N N Baranova, A A Neyfakh, R G Brennan
Crystal structure of MtaN, a global multidrug transporter gene activator.
J Biol Chem: 2001, 276(50);47178-84
[PubMed:11581256]
[WorldCat.org]
[DOI]
(P p)
M H Godsey, N N Baranova, A A Neyfakh, R G Brennan
Crystallization and preliminary X-ray diffraction studies on the DNA-binding domain of the multidrug transporter activation protein (MtaN) from Bacillus subtilis.
Acta Crystallogr D Biol Crystallogr: 2000, 56(Pt 11);1456-8
[PubMed:11053850]
[WorldCat.org]
[DOI]
(P p)
N N Baranova, A Danchin, A A Neyfakh
Mta, a global MerR-type regulator of the Bacillus subtilis multidrug-efflux transporters.
Mol Microbiol: 1999, 31(5);1549-59
[PubMed:10200972]
[WorldCat.org]
[DOI]
(P p)
