NagR

• Description: transcriptional regulator (GntR family)
  
  

Gene name	yvoA
Synonyms
Essential	no
Product	transcriptional regulator (GntR family)
Function	probably regulator of the putative nagA-nagB-yvoA operon
Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism
MW, pI	27 kDa, 6.768
Gene length, protein length	729 bp, 243 aa
Immediate neighbours	nagB, yvnB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU35030

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information: K(D) for N-acetylglucosamine-6-phosphate: 1 mM PubMed

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: N-acetylglucosamine-6-phosphate acts as the molecular inducer PubMed

• Interactions:

• Localization:

Database entries

• Structure: 2WVO PubMed

• UniProt: O34817

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Marcus Resch, Emile Schiltz, Fritz Titgemeyer, Yves A Muller
Insight into the induction mechanism of the GntR/HutC bacterial transcription regulator YvoA.
Nucleic Acids Res: 2010, 38(7);2485-97
[PubMed:20047956] [WorldCat.org] [DOI] (I p)

Marcus Resch, Heide Marie Roth, Mathias Kottmair, Madhumati Sevvana, Ralph Bertram, Fritz Titgemeyer, Yves A Muller
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of YvoA from Bacillus subtilis.
Acta Crystallogr Sect F Struct Biol Cryst Commun: 2009, 65(Pt 4);410-4
[PubMed:19342794] [WorldCat.org] [DOI] (I p)