RsbQ

• Description: protein serine phosphatase, energy PP2C, dephosphorylates RsbV
  
  

Gene name	rsbQ
Synonyms	yvfQ
Essential	no
Product	protein serine phosphatase, energy PP2C
Function	control of SigB activity
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	29 kDa, 5
Gene length, protein length	807 bp, 269 aa
Immediate neighbours	yvfR, rsbP
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU34100

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

Categories containing this gene/protein

protein modification, sigma factors and their control

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: AB hydrolase superfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: RsbQ-RsbP

• Localization:

Database entries

• Structure: 1WOM

• UniProt: O07015

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

• Chet Price, Davis, USA homepage

References

Margaret S Brody, Valley Stewart, Chester W Price
Bypass suppression analysis maps the signalling pathway within a multidomain protein: the RsbP energy stress phosphatase 2C from Bacillus subtilis.
Mol Microbiol: 2009, 72(5);1221-34
[PubMed:19432806] [WorldCat.org] [DOI] (I p)

Tomonori Kaneko, Nobuo Tanaka, Takashi Kumasaka
Crystal structures of RsbQ, a stress-response regulator in Bacillus subtilis.
Protein Sci: 2005, 14(2);558-65
[PubMed:15632289] [WorldCat.org] [DOI] (P p)

M S Brody, K Vijay, C W Price
Catalytic function of an alpha/beta hydrolase is required for energy stress activation of the sigma(B) transcription factor in Bacillus subtilis.
J Bacteriol: 2001, 183(21);6422-8
[PubMed:11591687] [WorldCat.org] [DOI] (P p)