Difference between revisions of "YngF"

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(Database entries)
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* '''Description:''' similar to 3-hydroxbutyryl-CoA dehydratase <br/><br/>
+
* '''Description:''' methylglutaconyl-CoA hydratase <br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|-
 
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || unknown
+
|style="background:#ABCDEF;" align="center"| '''Product''' || methylglutaconyl-CoA hydratase
 
|-
 
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || unknown
+
|style="background:#ABCDEF;" align="center"|'''Function''' || mother cell metabolism, leucine utilization
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 27 kDa, 7.671   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 27 kDa, 7.671   
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=== Basic information/ Evolution ===
 
=== Basic information/ Evolution ===
  
* '''Catalyzed reaction/ biological activity:'''  
+
* '''Catalyzed reaction/ biological activity:''' 3-methylglutaconyl-CoA --->(S)-3-hydroxy-3-methylglutaryl-CoA {{PubMed|19935659}}
  
 
* '''Protein family:''' enoyl-CoA hydratase/isomerase family (according to Swiss-Prot)
 
* '''Protein family:''' enoyl-CoA hydratase/isomerase family (according to Swiss-Prot)
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=References=
 
=References=
<pubmed>15699190,12662922 </pubmed>
+
<pubmed>15699190,12662922 19935659 </pubmed>
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 15:04, 26 November 2009

  • Description: methylglutaconyl-CoA hydratase

Gene name yngF
Synonyms
Essential no
Product methylglutaconyl-CoA hydratase
Function mother cell metabolism, leucine utilization
MW, pI 27 kDa, 7.671
Gene length, protein length 780 bp, 260 aa
Immediate neighbours yngE, yngG
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YngF context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU18220

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 3-methylglutaconyl-CoA --->(S)-3-hydroxy-3-methylglutaryl-CoA PubMed
  • Protein family: enoyl-CoA hydratase/isomerase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • expressed during sporulation in the mother cell (SigE) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Tzu-Lin Hsiao, Olga Revelles, Lifeng Chen, Uwe Sauer, Dennis Vitkup
Automatic policing of biochemical annotations using genomic correlations.
Nat Chem Biol: 2010, 6(1);34-40
[PubMed:19935659] [WorldCat.org] [DOI] (I p)

Leif Steil, Mónica Serrano, Adriano O Henriques, Uwe Völker
Genome-wide analysis of temporally regulated and compartment-specific gene expression in sporulating cells of Bacillus subtilis.
Microbiology (Reading): 2005, 151(Pt 2);399-420
[PubMed:15699190] [WorldCat.org] [DOI] (P p)

Patrick Eichenberger, Shane T Jensen, Erin M Conlon, Christiaan van Ooij, Jessica Silvaggi, José Eduardo González-Pastor, Masaya Fujita, Sigal Ben-Yehuda, Patrick Stragier, Jun S Liu, Richard Losick
The sigmaE regulon and the identification of additional sporulation genes in Bacillus subtilis.
J Mol Biol: 2003, 327(5);945-72
[PubMed:12662922] [WorldCat.org] [DOI] (P p)