Transcription factors of the LacI family

These transcription regulators resemble the E. coli Lac repressor (LacI). They are involved in the control of sugar catabolic operons in response to the availability of the carbon source. CcpA is the pleiotropic regulator of carbon catabolite repression.

• AraR
• CcpA
• CcpB
• DegA
• ExuR
• KdgR
• LacR
• MsmR
• NtdR
• RbsR
• YkvZ
• YvdE

Important publications

Francisco M Camas, Eric J Alm, Juan F Poyatos
Local gene regulation details a recognition code within the LacI transcriptional factor family.
PLoS Comput Biol: 2010, 6(11);e1000989
[PubMed:21085639] [WorldCat.org] [DOI] (I e)

Leslie Milk, Robert Daber, Mitchell Lewis
Functional rules for lac repressor-operator associations and implications for protein-DNA interactions.
Protein Sci: 2010, 19(6);1162-72
[PubMed:20512969] [WorldCat.org] [DOI] (I p)

Sudheer Tungtur, Sarah Meinhardt, Liskin Swint-Kruse
Comparing the functional roles of nonconserved sequence positions in homologous transcription repressors: implications for sequence/function analyses.
J Mol Biol: 2010, 395(4);785-802
[PubMed:19818797] [WorldCat.org] [DOI] (I p)

Liskin Swint-Kruse, Kathleen S Matthews
Allostery in the LacI/GalR family: variations on a theme.
Curr Opin Microbiol: 2009, 12(2);129-37
[PubMed:19269243] [WorldCat.org] [DOI] (I p)

Kaoru Fukami-Kobayashi, Yoshio Tateno, Ken Nishikawa
Parallel evolution of ligand specificity between LacI/GalR family repressors and periplasmic sugar-binding proteins.
Mol Biol Evol: 2003, 20(2);267-77
[PubMed:12598694] [WorldCat.org] [DOI] (P p)

C C Nguyen, M H Saier
Phylogenetic, structural and functional analyses of the LacI-GalR family of bacterial transcription factors.
FEBS Lett: 1995, 377(2);98-102
[PubMed:8543068] [WorldCat.org] [DOI] (P p)

M J Weickert, S Adhya
A family of bacterial regulators homologous to Gal and Lac repressors.
J Biol Chem: 1992, 267(22);15869-74
[PubMed:1639817] [WorldCat.org] (P p)