Difference between revisions of "ProA"
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=== Database entries === | === Database entries === | ||
− | * '''Structure:''' | + | * '''Structure:''' [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1O20 1O20] (from ''Thermotoga maritima'', 46% identity, 67% similarity) {{PubMed|14705032}} |
* '''UniProt:''' [http://www.uniprot.org/uniprot/P39821 P39821] | * '''UniProt:''' [http://www.uniprot.org/uniprot/P39821 P39821] |
Revision as of 11:35, 19 February 2010
- Description: glutamate-5-semialdehyde dehydrogenase
Gene name | proA |
Synonyms | |
Essential | no |
Product | glutamate-5-semialdehyde dehydrogenase |
Function | biosynthesis of proline |
Metabolic function and regulation of this protein in SubtiPathways: Pro, Stress | |
MW, pI | 45 kDa, 5.098 |
Gene length, protein length | 1245 bp, 415 aa |
Immediate neighbours | proB, ohrA |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
|
Contents
The gene
Basic information
- Locus tag: BSU13130
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH (according to Swiss-Prot)
- Protein family: gamma-glutamyl phosphate reductase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- UniProt: P39821
- KEGG entry: [2]
- E.C. number: 1.2.1.41
Additional information
Expression and regulation
- Regulatory mechanism:
- T-box: RNA switch, transcriptional antitermination PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Ana Gutiérrez-Preciado, Tina M Henkin, Frank J Grundy, Charles Yanofsky, Enrique Merino
Biochemical features and functional implications of the RNA-based T-box regulatory mechanism.
Microbiol Mol Biol Rev: 2009, 73(1);36-61
[PubMed:19258532]
[WorldCat.org]
[DOI]
(I p)