Difference between revisions of "CodY"
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=Expression and regulation= | =Expression and regulation= | ||
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| + | * '''Operon:''' ''[[codV]]-[[clpQ]]-[[clpY]]-[[codY]]'' {{PubMed|7783641}} | ||
| − | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|7783641}} | |
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| − | * '''[[Sigma factor]]:''' | ||
* '''Regulation:''' | * '''Regulation:''' | ||
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=References= | =References= | ||
| − | <pubmed>19542274,17493123,18641142,19202088,16995897,17982469,18083814,17993518,9287005,12618455,11331605,17218307,19500589,12591885,19202088,12618455,15802253,11331605,15228537,8793880,15937175,15916605,15916606,11331605,15228537 19749041 </pubmed> | + | <pubmed>19542274,17493123,18641142,19202088,16995897,17982469,18083814,17993518,9287005,12618455,11331605,17218307,19500589,12591885,19202088,12618455,15802253,11331605,15228537,8793880,15937175,15916605,15916606,11331605,15228537 19749041 7783641</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 16:47, 11 October 2009
- Description: regulation of a large regulon in response to branched-chain amino acid limitation
| Gene name | codY |
| Synonyms | |
| Essential | no |
| Product | transcriptional pleiotropic repressor |
| Function | regulation of a large regulon in response to
branched-chain amino acid limitation to the presence of branched-chain amino acids |
| MW, pI | 28 kDa, 4.75 |
| Gene length, protein length | 777 bp, 259 aa |
| Immediate neighbours | clpY, flgB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
The gene
Basic information
- Locus tag: BSU16170
Phenotypes of a mutant
No swarming motility on B medium. PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: codY family (according to Swiss-Prot)
- Paralogous protein(s):
Genes/ operons controlled by CodY
Extended information on the protein
- Kinetic information:
- Domains: contains a GAF domain (ligand binding domain)
- Modification: phosphorylation on Ser-215 PubMed
- Cofactor(s):
- Effectors of protein activity: GTP and branched chained amino acids (BCAA) increase the affinity of CodY for its DNA target sequences PubMed
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- UniProt: P39779
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant: GP566, available in Stülke lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Linc Sonenshein, Tufts University, Boston, MA, USA Homepage
Tony Wilkinson, York University, U.K. homepage
Oscar Kuipers, University of Groningen, The Netherlands Homepage
Your additional remarks
References
