Difference between revisions of "PlsX"
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=Expression and regulation= | =Expression and regulation= | ||
− | * '''Operon:''' | + | * '''Operon:''' ''[[fapR]]-[[plsX]]-[[fabD]]-[[fabG]]'' {{PubMed|12737802}} |
− | * '''[[Sigma factor]]:''' | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|16932747}} |
* '''Regulation:''' | * '''Regulation:''' | ||
− | ** repressed unless the cells experience | + | ** repressed unless the cells experience an accumulation of malonyl-CoA ([[FapR]]) {{PubMed|12737802}} |
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
− | ** [[FapR]]: transcription repression | + | ** [[FapR]]: transcription repression {{PubMed|12737802}} |
* '''Additional information:''' | * '''Additional information:''' | ||
Line 122: | Line 122: | ||
=References= | =References= | ||
− | <pubmed>12737802, 19282621, 17645809, 17557823, 8759840 </pubmed> | + | <pubmed>12737802, 19282621, 17645809, 17557823, 8759840 16932747</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] |
Revision as of 15:59, 11 October 2009
- Description: acyl-acyl carrier protein (ACP):phosphate acyltransferase
Gene name | plsX |
Synonyms | ylpD |
Essential | yes PubMed |
Product | acyl-acyl carrier protein (ACP):phosphate acyltransferase |
Function | biosynthesis of phospholipids |
MW, pI | 35 kDa, 5.492 |
Gene length, protein length | 999 bp, 333 aa |
Immediate neighbours | fapR, fabD |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
|
Contents
The gene
Basic information
- Locus tag: BSU15890
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: plsX family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
Database entries
- Structure: 1VI1
- UniProt: P71018
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system: B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Matsumoto lab PubMed
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Yoshinori Hara, Masahide Seki, Satoshi Matsuoka, Hiroshi Hara, Atsushi Yamashita, Kouji Matsumoto
Involvement of PlsX and the acyl-phosphate dependent sn-glycerol-3-phosphate acyltransferase PlsY in the initial stage of glycerolipid synthesis in Bacillus subtilis.
Genes Genet Syst: 2008, 83(6);433-42
[PubMed:19282621]
[WorldCat.org]
[DOI]
(P p)
Mika Yoshimura, Taku Oshima, Naotake Ogasawara
Involvement of the YneS/YgiH and PlsX proteins in phospholipid biosynthesis in both Bacillus subtilis and Escherichia coli.
BMC Microbiol: 2007, 7;69
[PubMed:17645809]
[WorldCat.org]
[DOI]
(I e)
Luciana Paoletti, Ying-Jie Lu, Gustavo E Schujman, Diego de Mendoza, Charles O Rock
Coupling of fatty acid and phospholipid synthesis in Bacillus subtilis.
J Bacteriol: 2007, 189(16);5816-24
[PubMed:17557823]
[WorldCat.org]
[DOI]
(P p)
Gustavo E Schujman, Marcelo Guerin, Alejandro Buschiazzo, Francis Schaeffer, Leticia I Llarrull, Georgina Reh, Alejandro J Vila, Pedro M Alzari, Diego de Mendoza
Structural basis of lipid biosynthesis regulation in Gram-positive bacteria.
EMBO J: 2006, 25(17);4074-83
[PubMed:16932747]
[WorldCat.org]
[DOI]
(P p)
Gustavo E Schujman, Luciana Paoletti, Alan D Grossman, Diego de Mendoza
FapR, a bacterial transcription factor involved in global regulation of membrane lipid biosynthesis.
Dev Cell: 2003, 4(5);663-72
[PubMed:12737802]
[WorldCat.org]
[DOI]
(P p)
H R Morbidoni, D de Mendoza, J E Cronan
Bacillus subtilis acyl carrier protein is encoded in a cluster of lipid biosynthesis genes.
J Bacteriol: 1996, 178(16);4794-800
[PubMed:8759840]
[WorldCat.org]
[DOI]
(P p)