Difference between revisions of "TrpP"
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=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' | + | * '''Operon:''' ''[[trpP]]'' {{PubMed|10735881}} |
| − | * '''[[Sigma factor]]:''' | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|10735881}} |
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** induced in the absence of tryptophan ([[MtrB]]) {{PubMed|10735881}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| + | ** [[MtrB]]: translation inhibition, the [[MtrB]] binding site overlaps the Shine-DAlgarno sequence and translation initation region, [[MtrB]] binds in the presence of tryptophan {{PubMed|10735881}} | ||
| − | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = | ||
Revision as of 19:36, 16 September 2009
- Description: L-tryptophan transporter (proton symport)
| Gene name | trpP |
| Synonyms | yhaG |
| Essential | no |
| Product | L-tryptophan transporter (proton symport) |
| Function | tryptophan uptake |
| Metabolic function and regulation of this protein in SubtiPathways: Phe, Tyr, Trp | |
| MW, pI | 18 kDa, 11.155 |
| Gene length, protein length | 516 bp, 172 aa |
| Immediate neighbours | yhaH, serC |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU10010
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: trpP transporter family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: O07515
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Helen Yakhnin, Hong Zhang, Alexander V Yakhnin, Paul Babitzke
The trp RNA-binding attenuation protein of Bacillus subtilis regulates translation of the tryptophan transport gene trpP (yhaG) by blocking ribosome binding.
J Bacteriol: 2004, 186(2);278-86
[PubMed:14702295]
[WorldCat.org]
[DOI]
(P p)
J P Sarsero, E Merino, C Yanofsky
A Bacillus subtilis gene of previously unknown function, yhaG, is translationally regulated by tryptophan-activated TRAP and appears to be involved in tryptophan transport.
J Bacteriol: 2000, 182(8);2329-31
[PubMed:10735881]
[WorldCat.org]
[DOI]
(P p)
