Difference between revisions of "HisC"
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=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' | + | * '''Operon:''' ''[[trpE]]-[[trpD]]-[[trpC]]-[[trpF]]-[[trpB]]-[[trpA]]-[[hisC]]-[[tyrA]]-[[aroE]]'' {{PubMed|3924737}} |
| − | * '''[[Sigma factor]]:''' | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|6436812}} |
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** induction by tryptophan ([[MtrB| TRAP]]) {{PubMed|1551827}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| + | ** [[MtrB| TRAP]]: binding to the mRNA in the presence of tryptophan, this results in transcription termination {{PubMed|8419914}} | ||
| − | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = | ||
Revision as of 19:37, 29 October 2009
- Description: histidinol-phosphate aminotransferase / tyrosine and phenylalanine aminotransferase
| Gene name | hisC |
| Synonyms | aroJ |
| Essential | no |
| Product | histidinol-phosphate aminotransferase / tyrosine and phenylalanine aminotransferase |
| Function | biosynthesis of aromatic amino acids |
| Metabolic function and regulation of this protein in SubtiPathways: Phe, Tyr, Trp, His | |
| MW, pI | 39 kDa, 5.005 |
| Gene length, protein length | 1080 bp, 360 aa |
| Immediate neighbours | tyrA, trpA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
| |
Contents
The gene
Basic information
- Locus tag: BSU22620
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate (according to Swiss-Prot)
- Protein family: bacterial solute-binding protein 3 family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Swiss prot entry: P17731
- KEGG entry: [3]
- E.C. number: 2.6.1.9
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
D A Weigent, E W Nester
Regulation of histidinol phosphate aminotransferase synthesis by tryptophan in Bacillus subtilis.
J Bacteriol: 1976, 128(1);202-11
[PubMed:824269]
[WorldCat.org]
[DOI]
(P p)
E W Nester, A L Montoya
An enzyme common to histidine and aromatic amino acid biosynthesis in Bacillus subtilis.
J Bacteriol: 1976, 126(2);699-705
[PubMed:4431]
[WorldCat.org]
[DOI]
(P p)
