Difference between revisions of "GbsA"
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=== Database entries === | === Database entries === | ||
− | * '''Structure:''' | + | * '''Structure:''' [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1WND 1WND] (from ''Escherichia coli k12 mutant'', 36% identity, 54% similarity) {{PubMed|15381418}} |
* '''UniProt:''' [http://www.uniprot.org/uniprot/P71016 P71016] | * '''UniProt:''' [http://www.uniprot.org/uniprot/P71016 P71016] |
Revision as of 10:32, 18 February 2010
- Description: glycine betaine-aldehyde dehydrogenase, glycine betaine synthesis
Gene name | gbsA |
Synonyms | |
Essential | no |
Product | glycine betaine-aldehyde dehydrogenase |
Function | osmoprotection |
Metabolic function and regulation of this protein in SubtiPathways: Stress | |
MW, pI | 53 kDa, 4.713 |
Gene length, protein length | 1470 bp, 490 aa |
Immediate neighbours | gbsB, yuaC |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
|
Contents
The gene
Basic information
- Locus tag: BSU31060
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Betaine aldehyde + NAD+ + H2O = betaine + NADH (according to Swiss-Prot)
- Protein family: aldehyde dehydrogenase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- UniProt: P71016
- KEGG entry: [2]
- E.C. number: 1.2.1.8
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Erhard Bremer, University of Marburg, Germany homepage
Your additional remarks
References
J Boch, G Nau-Wagner, S Kneip, E Bremer
Glycine betaine aldehyde dehydrogenase from Bacillus subtilis: characterization of an enzyme required for the synthesis of the osmoprotectant glycine betaine.
Arch Microbiol: 1997, 168(4);282-9
[PubMed:9297465]
[WorldCat.org]
[DOI]
(P p)
J Boch, B Kempf, R Schmid, E Bremer
Synthesis of the osmoprotectant glycine betaine in Bacillus subtilis: characterization of the gbsAB genes.
J Bacteriol: 1996, 178(17);5121-9
[PubMed:8752328]
[WorldCat.org]
[DOI]
(P p)