HisJ

• Description: histidinol phosphate phosphatase
  
  

Gene name	hisJ
Synonyms	ytvP
Essential	no
Product	histidinol phosphate phosphatase
Function	biosynthesis of histidine
Metabolic function and regulation of this protein in SubtiPathways: His
MW, pI	30 kDa, 5.061
Gene length, protein length	804 bp, 268 aa
Immediate neighbours	ezrA, yttP
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU29620

Phenotypes of a mutant

auxotroph for histidine

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: L-histidinol phosphate + H₂O = L-histidinol + phosphate (according to Swiss-Prot)

• Protein family: HisK subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O34411

• KEGG entry: [2]

• E.C. number: 3.1.3.15

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Stephane Aymerich, Microbiology and Molecular Genetics, INRA Paris-Grignon, France

References

D le Coq, S Fillinger, S Aymerich
Histidinol phosphate phosphatase, catalyzing the penultimate step of the histidine biosynthesis pathway, is encoded by ytvP (hisJ) in Bacillus subtilis.
J Bacteriol: 1999, 181(10);3277-80
[PubMed:10322033] [WorldCat.org] [DOI] (P p)