Difference between revisions of "HemC"
(→Expression and regulation) |
|||
| Line 89: | Line 89: | ||
=Expression and regulation= | =Expression and regulation= | ||
| + | * '''Operon:''' ''[[hemA]]-[[hemX]]-[[hemC]]-[[hemD]]-[[hemB]]-[[hemL]]'' {{PubMed|1672867}} | ||
| − | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|1672867}} | |
| − | |||
| − | * '''[[Sigma factor]]:''' | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| − | ** | + | ** induced by hydrogen peroxide ([[PerR]]) {{PubMed|11532148}} |
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| − | ** [[PerR]]: transcription repression | + | ** [[PerR]]: transcription repression {{PubMed|11532148}} |
| − | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = | ||
Revision as of 19:58, 13 December 2009
- Description: hydroxymethylbilane synthase
| Gene name | hemC |
| Synonyms | |
| Essential | no |
| Product | hydroxymethylbilane synthase |
| Function | heme biosynthesis |
| MW, pI | 34 kDa, 5.088 |
| Gene length, protein length | 942 bp, 314 aa |
| Immediate neighbours | hemD, hemX |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU28150
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3 (according to Swiss-Prot)
- Protein family: HMBS family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: P16616
- KEGG entry: [3]
- E.C. number: 2.5.1.61
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
A F Herbig, J D Helmann
Roles of metal ions and hydrogen peroxide in modulating the interaction of the Bacillus subtilis PerR peroxide regulon repressor with operator DNA.
Mol Microbiol: 2001, 41(4);849-59
[PubMed:11532148]
[WorldCat.org]
[DOI]
(P p)
Per Johansson, Lars Hederstedt
Organization of genes for tetrapyrrole biosynthesis in gram--positive bacteria.
Microbiology (Reading): 1999, 145 ( Pt 3);529-538
[PubMed:10217486]
[WorldCat.org]
[DOI]
(P p)
M Hansson, L Rutberg, I Schröder, L Hederstedt
The Bacillus subtilis hemAXCDBL gene cluster, which encodes enzymes of the biosynthetic pathway from glutamate to uroporphyrinogen III.
J Bacteriol: 1991, 173(8);2590-9
[PubMed:1672867]
[WorldCat.org]
[DOI]
(P p)
