Difference between revisions of "NadR"
| Line 87: | Line 87: | ||
=Expression and regulation= | =Expression and regulation= | ||
| + | * '''Operon:''' ''[[nifS]]-[[nadR]]'' {{PubMed|8444804}} | ||
| − | * ''' | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|8444804}} |
| − | |||
| − | |||
* '''Regulation:''' | * '''Regulation:''' | ||
| − | ** repressed in the presence of nicotinic acid ([[NadR]]) | + | ** repressed in the presence of nicotinic acid ([[NadR]]) {{PubMed|8444804,16199587}} |
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| − | ** [[NadR]]: transcription repression | + | ** [[NadR]]: transcription repression {{PubMed|8444804,16199587}} |
| − | |||
* '''Additional information:''' | * '''Additional information:''' | ||
| Line 122: | Line 120: | ||
=References= | =References= | ||
| − | <pubmed>18276644, | + | <pubmed>18276644,8444804,16199587, </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 20:24, 26 November 2009
- Description: transcriptional repressor of genes involved in NAD biosynthesis
| Gene name | nadR |
| Synonyms | yrxA |
| Essential | no |
| Product | transcriptional repressor |
| Function | regulation of NAD biosynthesis |
| MW, pI | 19 kDa, 5.759 |
| Gene length, protein length | 534 bp, 178 aa |
| Immediate neighbours | nifS, pheA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU27890
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: P39667
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Alessandra Albertini, University of Pavia, Italy homepage
Your additional remarks
References
Dmitry A Rodionov, Xiaoqing Li, Irina A Rodionova, Chen Yang, Leonardo Sorci, Etienne Dervyn, Dariusz Martynowski, Hong Zhang, Mikhail S Gelfand, Andrei L Osterman
Transcriptional regulation of NAD metabolism in bacteria: genomic reconstruction of NiaR (YrxA) regulon.
Nucleic Acids Res: 2008, 36(6);2032-46
[PubMed:18276644]
[WorldCat.org]
[DOI]
(I p)
Paola Rossolillo, Ilaria Marinoni, Elisa Galli, Anna Colosimo, Alessandra M Albertini
YrxA is the transcriptional regulator that represses de novo NAD biosynthesis in Bacillus subtilis.
J Bacteriol: 2005, 187(20);7155-60
[PubMed:16199587]
[WorldCat.org]
[DOI]
(P p)
D Sun, P Setlow
Cloning, nucleotide sequence, and regulation of the Bacillus subtilis nadB gene and a nifS-like gene, both of which are essential for NAD biosynthesis.
J Bacteriol: 1993, 175(5);1423-32
[PubMed:8444804]
[WorldCat.org]
[DOI]
(P p)
