Difference between revisions of "FolD"
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=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' ''[[nusB]]-[[folD]]'' | + | * '''Operon:''' ''[[nusB]]-[[folD]]'' {{PubMed|2536750,11591660}} |
* '''[[Sigma factor]]:''' | * '''[[Sigma factor]]:''' | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| − | ** repressed in the presence of purine nucleotides ([[PurR]]) | + | ** repressed in the presence of purine nucleotides ([[PurR]]) {{PubMed|2536750,11591660}} |
| − | |||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| − | + | ** [[PurR]]: transcription repression (molecular inducer: PRPP) {{PubMed|2536750,11591660}} | |
| − | ** [[PurR]]: transcription repression (molecular inducer: PRPP) | ||
* '''Additional information:''' | * '''Additional information:''' | ||
Revision as of 20:04, 20 November 2009
- Description: methylenetetrahydrofolate dehydrogenase (NADP)
| Gene name | folD |
| Synonyms | yqiA |
| Essential | yes PubMed |
| Product | methylenetetrahydrofolate dehydrogenase (NADP) |
| Function | formylation of Met-tRNA(fMet) |
| MW, pI | 30 kDa, 5.6 |
| Gene length, protein length | 849 bp, 283 aa |
| Immediate neighbours | yqiB, nusB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
The gene
Basic information
- Locus tag: BSU24310
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH (according to Swiss-Prot)
- Protein family: tetrahydrofolate dehydrogenase/cyclohydrolase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P54382
- KEGG entry: [3]
- E.C. number: 1.5.1.5
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
