Difference between revisions of "Xpt"
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=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' ''[[xpt]]-[[pbuX]]'' | + | * '''Operon:''' ''[[xpt]]-[[pbuX]]'' {{PubMed|9098051}} |
| − | * '''[[Sigma factor]]:''' | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|9098051}} |
* '''Regulation:''' | * '''Regulation:''' | ||
| − | |||
** repressed in the presence of adenine or adenosine ([[PurR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/11591660 PubMed] | ** repressed in the presence of adenine or adenosine ([[PurR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/11591660 PubMed] | ||
** induced in the absence of guanine ([[G-box]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12787499 PubMed] | ** induced in the absence of guanine ([[G-box]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12787499 PubMed] | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| − | + | ** [[G-box]]: transcription termination/ antitermination ([[riboswitch]]) {{PubMed|9098051,12787499}} | |
| − | ** [[G-box]]: transcription termination/ antitermination ([[riboswitch]]) | ||
** [[PurR]]: transcription repression (molecular inducer: PRPP) [http://www.ncbi.nlm.nih.gov/sites/entrez/11591660 PubMed] | ** [[PurR]]: transcription repression (molecular inducer: PRPP) [http://www.ncbi.nlm.nih.gov/sites/entrez/11591660 PubMed] | ||
| − | * '''Additional information:''' subject to Clp-dependent proteolysis upon glucose starvation | + | * '''Additional information:''' subject to Clp-dependent proteolysis upon glucose starvation {{PubMed|17981983}} |
=Biological materials = | =Biological materials = | ||
Revision as of 20:23, 26 October 2009
- Description: xanthine phosphoribosyltransferase
| Gene name | xpt |
| Synonyms | |
| Essential | no |
| Product | xanthine phosphoribosyltransferase |
| Function | purine salvage and interconversion |
| Metabolic function and regulation of this protein in SubtiPathways: Purine salvage, Nucleotides (regulation) | |
| MW, pI | 20 kDa, 5.835 |
| Gene length, protein length | 582 bp, 194 aa |
| Immediate neighbours | pbuX, ypwA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU22070
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine (according to Swiss-Prot)
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- UniProt: P42085
- KEGG entry: [3]
- E.C. number: 2.4.2.22
Additional information
- subject to Clp-dependent proteolysis upon glucose starvation PubMed
Expression and regulation
- Regulation:
- Regulatory mechanism:
- G-box: transcription termination/ antitermination (riboswitch) PubMed
- PurR: transcription repression (molecular inducer: PRPP) PubMed
- Additional information: subject to Clp-dependent proteolysis upon glucose starvation PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
