AccC

• Description: acetyl-CoA carboxylase (biotin carboxylase UE)
  
  

Gene name	accC
Synonyms	yqhX
Essential	yes PubMed
Product	acetyl-CoA carboxylase (biotin carboxylase UE))
Function	production of malonyl-CoA, the substrate for fatty acid biosynthesis
MW, pI	49 kDa, 4.72
Gene length, protein length	1350 bp, 450 aa
Immediate neighbours	yqhY, accB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU24340

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + biotin-carboxyl-carrier protein + CO₂ = ADP + phosphate + carboxybiotin-carboxyl-carrier protein (according to Swiss-Prot)

• Protein family:

• Paralogous protein(s): YotE

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P49787

• KEGG entry: [3]

• E.C. number: 6.3.4.14

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

P Marini, S J Li, D Gardiol, J E Cronan, D de Mendoza
The genes encoding the biotin carboxyl carrier protein and biotin carboxylase subunits of Bacillus subtilis acetyl coenzyme A carboxylase, the first enzyme of fatty acid synthesis.
J Bacteriol: 1995, 177(23);7003-6
[PubMed:7592499] [WorldCat.org] [DOI] (P p)