SalA

• Description: negative regulator of scoC expression
  
  

Gene name	salA
Synonyms	ybaL
Essential	no
Product	MRP family regulator
Function	control of alkaline protease expression
MW, pI	38 kDa, 5.23
Gene length, protein length	1056 bp, 352 aa
Immediate neighbours	cwlD, gerD
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU01540

Phenotypes of a mutant

increased expression of aprE (due to loss of repression of scoC expression)

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: negative regulation of scoC expression

• Protein family: Mrp/NBP35 ATP-binding proteins family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• Swiss prot entry: P50863

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation: negative autoregulation

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant: TMB083 (tet), available in Thorsten Mascher lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Mitsuo Ogura, Atsushi Matsuzawa, Hirofumi Yoshikawa, Teruo Tanaka
Bacillus subtilis SalA (YbaL) negatively regulates expression of scoC, which encodes the repressor for the alkaline exoprotease gene, aprE.
J Bacteriol: 2004, 186(10);3056-64
[PubMed:15126467] [WorldCat.org] [DOI] (P p)