Difference between revisions of "FeuC"

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(Expression and regulation)
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=Expression and regulation=
 
=Expression and regulation=
  
* '''Operon:'''  
+
* '''Operon:''' ''[[feuA]]-[[feuB]]-[[feuC]]-[[ybbA]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]
  
* '''[[Sigma factor]]:'''  
+
* '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
** repressed unless the cells enter an iron starvation ([[Fur]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]
+
** repressed in the presence of iron ([[Fur]], [[CitB]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]
 +
** induced in the presence of iron chelators bacillibactin or enterobactin ([[Btr]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 
** [[Fur]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]
 
** [[Fur]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]
 +
** [[CitB]]: binding to the iron responsive element in the absence of iron
 +
** [[Btr]]: transcription activation in the presence of the co-activators bacillibactin or enterobactin [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]
  
* '''Additional information:'''  
+
* '''Additional information:'''
  
 
=Biological materials =
 
=Biological materials =

Revision as of 20:10, 27 June 2009

  • Description: ABC-transporter for the siderophores enterobactin and bacillibactin (integral membrane protein)

Gene name feuC
Synonyms
Essential no
Product ABC-transporter for the siderophores enterobactin and
bacillibactin (integral membrane protein)
Function iron acquisition
Metabolic function and regulation of this protein in SubtiPathways:
Stress
MW, pI 42 kDa, 10.435
Gene length, protein length 1182 bp, 394 aa
Immediate neighbours ybbA, feuB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
FeuC context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU01610

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: FecCD subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed in the presence of iron (Fur, CitB) PubMed
    • induced in the presence of iron chelators bacillibactin or enterobactin (Btr) PubMed
  • Regulatory mechanism:
    • Fur: transcription repression PubMed
    • CitB: binding to the iron responsive element in the absence of iron
    • Btr: transcription activation in the presence of the co-activators bacillibactin or enterobactin PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References