mmgA

mmgA
168

degradative acetoacetyl-CoA thiolase

Locus
BSU_24170
Molecular weight
41.02 kDa
Isoelectric point
5.9
Protein length
393 aaSequenceBlast
Gene length
1182 bpSequenceBlast
Function
mother cell metabolism, leucine utilization
Product
degradative acetoacetyl-CoA thiolase
Essential
no
E.C.
2.3.1.9
Synonyms
mmgA, yqiL
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0183 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,512,861  2,514,042
The protein
Catalyzed reaction/ biological activity
2 acetyl-CoA --> CoA + acetoacetyl-CoA  PubMed
Protein family
thiolase-like superfamily (according to UniProt)
Structure
3SS6 (PDB) (the protein of B. anthracis, 44% identity, 73% similarity)
P45855 (AlphaFold)
Paralogous protein(s)
YhfS, FadA
Expression and Regulation
Operons
Genes
mmgA-mmgB-mmgC-mmgD-mmgE-mmgF
Description
PubMed
Regulation
expressed early during sporulation in the mother cell (SigE) PubMed
strongly expressed during oligotrophic growth PubMed
Regulatory mechanism
CcpA: repression, PubMed, in ccpA regulon
Sigma factors
SigE: sigma factor, PubMed, in sigE regulon
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mmgA→mmgF

2025-04-08 07:22:48

Jstuelk

111

be5c5568e93dc96bd335d396c9ced168a6874b5d

43FB5BE81B1A707E4F1C97099736CD2DD49A154C

Biological materials
Mutant
BKE24170 (mmgA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGGTTTCACCTCATTCAG,  downstream forward: _UP4_TAAAACATGATGAAAAAGGG
BKK24170 (mmgA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGGTTTCACCTCATTCAG,  downstream forward: _UP4_TAAAACATGATGAAAAAGGG
References
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226100C0AC13BB345DB0F0F309DEB7F91F3770B0

Page visits: 5026

Time of last update: 2025-04-09 05:52:22

Author of last update: Melvin.boenninger