galE
168

UDP glucose 4-epimerase

Locus

BSU_38860

Molecular weight

36.85 kDa

Isoelectric point

4.78

Protein length

339 aaSequenceBlast

Gene length

1020 bpSequenceBlast

Function

galactose utilization

Product

UDP glucose 4-epimerase

Essential

E.C.

5.1.3.2

Synonyms

galE

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1087 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

3,989,948 3,990,967

Phenotypes of a mutant

smooth colonies on MsGG medium, no biofilm formation in the absence of externally provided galactose PubMed

the mutant is sensitive to exogenous galactose due to the accumulation of toxic UDP-galactose, this sensitivity can be suppressed by the inactivation of ''galK (no formation of the toxic UDP-galactose) or of sinR (constitutive expression of the epsA-epsB-epsC-epsD-epsE-epsF-epsG-epsH-epsI-epsJ-epsK-epsL-epsM-epsN-epsO'' results in detoxification of UDP-galactose) PubMed

The protein

Catalyzed reaction/ biological activity

UDP-α-D-galactose --> UDP-α-D-glucose (according to UniProt)

Protein family

NAD(P)-dependent epimerase/dehydratase family (according to UniProt)

Structure

1LRL (PDB) (from Escherichia coli Y299C mutant, 57% identity, 71% similarity)\tPubMed

P55180 (AlphaFold)

Expression and Regulation

Operons

Genes

galE