feuC

feuC
168

ABC transporter for the siderophores Fe-enterobactin and Fe-bacillibactin (integral membrane protein)

Locus
BSU_01610
Molecular weight
42.91 kDa
Isoelectric point
10.44
Protein length
336 aaSequenceBlast
Gene length
1011 bpSequenceBlast
Function
acquisition of iron
Product
ABC transporter for the siderophores Fe-enterobactin and Fe-bacillibactin (integral membrane protein)
Essential
no
Synonyms
feuC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0609 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
180,344 → 181,354
Phenotypes of a mutant
severe growth inhibition upon addition of subinhibitory concentrations of mirubactin C PubMed
The protein
Protein family
Binding-protein-dependent transport system permease family (according to UniProt)
FecCD subfamily (according to UniProt)
Structure
4G1U (PDB) (heme transporter from Yersinia pestis, 31% identity) PubMed
P40411 (AlphaFold)
Paralogous protein(s)
FhuG
Localization
cell membrane PubMed
Expression and Regulation
Operons
Genes
feuA-feuB-feuC-ybbA
Description
PubMed
Regulation
expression during spore germination is strongly reduced under conditions of osmotic stress PubMed
induced by iron starvation (second wave to allow iron scavenging from the environment) (Fur) PubMed
Regulatory mechanism
Fur: repression, PubMed, in fur regulon
Btr: activation, in the presence of the co-activators bacillibactin or enterobactin PubMed, in btr regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Additional information
the presence of an iron-responsive element bound by CitB between ''feuA and feuB'' suggests iron-dependent regulation by CitB PubMed
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feuA→ybbA

2025-04-07 01:53:26

Jstuelk

120

c6ed9c562a4c7db452ebc8903a1989d0bb2f0947

A3C1B309E9C3034B9896B74BA25621D2CF69902F

Other regulations
CitB: translation control
Biological materials
Mutant
BKE01610 (ΔfeuC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAAGCGATGAACAATGCAT,  downstream forward: _UP4_AAGCAAAAAAAGGGGGAGAA
BKK01610 (ΔfeuC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAAGCGATGAACAATGCAT,  downstream forward: _UP4_AAGCAAAAAAAGGGGGAGAA
References
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Time of last update: 2025-04-07 09:44:01

Author of last update: Jstuelk