yxbB

yxbB
168

similar to S-adenosyl-L-methionine-dependent methyltransferase

Locus
BSU_39890
Molecular weight
28.07 kDa
Isoelectric point
4.57
Protein length
244 aaSequenceBlast
Gene length
735 bpSequenceBlast
Function
unknown
Product
putative S-adenosyl-L-methionine-dependent methyltransferase
Essential
no
Synonyms
yxbB, yxaP
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2226 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
4,097,416  4,098,150
The protein
Protein family
Methyltransferase superfamily (according to UniProt)
Structure
3DLC (PDB) (from Methanococcus maripaludis, corresponds to aa 21 ... 193, 30% identity)
P46326 (AlphaFold)
Expression and Regulation
Operons
Genes
yxbB-yxbA-yxnB
Description
PubMed
Regulation
repressed by glucose (8-fold) PubMed
Regulatory mechanism
CodY: repression, PubMed, in codY regulon
AbrB: repression, PubMed, in abrB regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

yxbB→yxnB

2025-04-05 04:55:55

ghost

88

4e575af872ba95e2cf90fe572e62500dbeeb237b

313B46B7C64D64F3047B680AB2010FF8D128F6EB

Genes
yxbB-yxbA-yxnB-asnH-yxaM
Description
PubMed
Regulation
repressed by glucose (8-fold) PubMed
Regulatory mechanism
CodY: repression, PubMed, in codY regulon
AbrB: repression, PubMed, in abrB regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

yxbB→yxaM

2025-03-26 15:53:41

ghost

90

b92c3bd2849e2809ddcc3c320eae6fb9d682a8b4

5C58E2063585752CCDF4E84423501D1D48511254

Biological materials
Mutant
MGNA-B690 (yxbB::erm), available at the NBRP B. subtilis, Japan
BKE39890 (yxbB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTTCAGCATCCTCCTTA,  downstream forward: _UP4_AAAGAAAAGGAAGGTGCATT
BKK39890 (yxbB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTTCAGCATCCTCCTTA,  downstream forward: _UP4_AAAGAAAAGGAAGGTGCATT
References
Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J RNA processing in Bacillus subtilis: identification of targets of the essential RNase Y. Molecular microbiology. 2011 Sep; 81(6):1459-73. doi:10.1111/j.1365-2958.2011.07777.x. PMID:21815947
Irnov I, Sharma CM, Vogel J, Winkler WC Identification of regulatory RNAs in Bacillus subtilis. Nucleic acids research. 2010 Oct; 38(19):6637-51. doi:10.1093/nar/gkq454. PMID:20525796
Morinaga T, Kobayashi K, Ashida H, Fujita Y, Yoshida K Transcriptional regulation of the Bacillus subtilis asnH operon and role of the 5'-proximal long sequence triplication in RNA stabilization. Microbiology (Reading, England). 2010 Jun; 156(Pt 6):1632-41. doi:10.1099/mic.0.036582-0. PMID:20185509
Belitsky BR, Sonenshein AL Genetic and biochemical analysis of CodY-binding sites in Bacillus subtilis. Journal of bacteriology. 2008 Feb; 190(4):1224-36. . PMID:18083814
Hamon MA, Stanley NR, Britton RA, Grossman AD, Lazazzera BA Identification of AbrB-regulated genes involved in biofilm formation by Bacillus subtilis. Molecular microbiology. 2004 May; 52(3):847-60. . PMID:15101989
Blencke HM, Homuth G, Ludwig H, Mäder U, Hecker M, Stülke J Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways. Metabolic engineering. 2003 Apr; 5(2):133-49. . PMID:12850135
Molle V, Nakaura Y, Shivers RP, Yamaguchi H, Losick R, Fujita Y, Sonenshein AL Additional targets of the Bacillus subtilis global regulator CodY identified by chromatin immunoprecipitation and genome-wide transcript analysis. Journal of bacteriology. 2003 Mar; 185(6):1911-22. . PMID:12618455
Molle V, Nakaura Y, Shivers RP, Yamaguchi H, Losick R, Fujita Y, Sonenshein AL Additional targets of the Bacillus subtilis global regulator CodY identified by chromatin immunoprecipitation and genome-wide transcript analysis. Journal of bacteriology. 2003 Mar; 185(6):1911-22. . PMID:12618455
Yoshida K, Ishio I, Nagakawa E, Yamamoto Y, Yamamoto M, Fujita Y Systematic study of gene expression and transcription organization in the gntZ-ywaA region of the Bacillus subtilis genome. Microbiology (Reading, England). 2000 Mar; 146 ( Pt 3):573-9. . PMID:10746760
Yoshida K, Fujita Y, Ehrlich SD Three asparagine synthetase genes of Bacillus subtilis. Journal of bacteriology. 1999 Oct; 181(19):6081-91. . PMID:10498721

787BB72119DB1321A8281D7C46FED28CAEDBC97C

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Time of last update: 2025-04-05 17:15:58

Author of last update: Jstuelk