sufA

sufA
168

Fe-S carrier protein

Locus
BSU_32160
Molecular weight
12.61 kDa
Isoelectric point
4.52
Protein length
120 aaSequenceBlast
Gene length
363 bpSequenceBlast
Function
assembly of Fe-S clusters
Product
Fe-S carrier
Essential
no
Synonyms
sufA, yutM
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

List of homologs in different organisms, belongs to COG0316 (Galperin et al., 2021)

Gene
Coordinates
3,305,599  3,305,961
The protein
Protein family
HesB/IscA family (with PdhI, according to UniProt)
Cofactors
Fe-S cluster PubMed
Structure
1R94 (PDB) (from E. coli) PubMed
O32113 (AlphaFold)
Expression and Regulation
Operons
Genes
sufA
Description
PubMed
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sufA

2025-04-02 15:28:34

Jstuelk

59

499f7d247f7adfed3db0a5e169761e8897a79411

041F2D5A17D5559B50310BB959EB89F628BD54FA

Genes
dapF-sufA
Description
PubMed
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dapF→sufA

2025-04-02 15:30:34

Jstuelk

90

cb67469c37f698f5888cb5accc1ac921d00650b0

F8FF2423BEC3A4415C691F58C9990C193330CF09

Biological materials
Mutant
MGNA-A969 (yutM::erm), available at the NBRP B. subtilis, Japan
BKE32160 (sufA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCATTATGAACCTCCTTT,  downstream forward: _UP4_TAAGCACTAAAAACGGATAG
BKK32160 (sufA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCATTATGAACCTCCTTT,  downstream forward: _UP4_TAAGCACTAAAAACGGATAG
References
Kwon E, Dahal P, Kim DYCrystal structure and biochemical analysis suggest that YjoB ATPase is a putative substrate-specific molecular chaperone.Proceedings of the National Academy of Sciences of the United States of America. 2022 Oct 11; 119(41):e2207856119. PMID: 36191235
Albrecht AG, Netz DJ, Miethke M, Pierik AJ, Burghaus O, Peuckert F, Lill R, Marahiel MA SufU is an essential iron-sulfur cluster scaffold protein in Bacillus subtilis. Journal of bacteriology. 2010 Mar; 192(6):1643-51. doi:10.1128/JB.01536-09. PMID:20097860
Bilder PW, Ding H, Newcomer ME Crystal structure of the ancient, Fe-S scaffold IscA reveals a novel protein fold. Biochemistry. 2004 Jan 13; 43(1):133-9. . PMID:14705938

94A3B5EF4ADCFA57A204B584B6D305A62E3E15AE

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Time of last update: 2025-04-05 19:32:37

Author of last update: Jstuelk