ugd

ugd
168

UDP-glucose dehydrogenase

Locus
BSU_36230
Molecular weight
47.62 kDa
Isoelectric point
5.03
Protein length
440 aaSequenceBlast
Gene length
1323 bpSequenceBlast
Function
unknown
Product
UDP-glucose dehydrogenase
Essential
no
E.C.
1.1.1.22
Synonyms
ugd, ywqF
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1004 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,729,488  3,730,810
The protein
Catalyzed reaction/ biological activity
H2O + 2 NAD+ + UDP-α-D-glucose --> 3 H+ + 2 NADH + UDP-α-D-glucuronate (according to UniProt)
Protein family
UDP-glucose/GDP-mannose dehydrogenase family (with TuaD and YtcA, according to UniProt)
Structure
3GG2 (PDB) (from Porphyromonas gingivalis, 45% identity)
P96718 (AlphaFold)
Modification
phosphorylation on Tyr-70 by PtkA PubMed, dephosphorylated by PtpZ PubMed
Effectors of protein activity
phosphorylation by PtkA stimulates activity of Ugd PubMed
Paralogous protein(s)
YtcA, TuaD
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
tkmA-ptkA-ptpZ-ugd
Description
PubMed
Regulatory mechanism
Spo0A: activation, PubMed, in spo0A regulon
DegU: activation, DegU-P, PubMed, in degU regulon
AbrB: repression, PubMed, in abrB regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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tkmA→ugd

2025-03-17 18:24:39

ghost

105

c2e9da4a42fde0cc0e5b798663a12ae407bf7d28

23621A956181A8BE93792267290B609197EA8EF4

Biological materials
Mutant
BKE36230 (ugd::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTGTTTCCCTCCAACAGT,  downstream forward: _UP4_TAGATGAAAAAGAAAGGCTG
References
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45AFD434F5262BFBE4ED6DF3D18DAED61FF317D1

Page visits: 5924

Time of last update: 2025-04-08 06:11:02

Author of last update: Melvin.boenninger