Difference between revisions of "MhqR"
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|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of resistance to quinones and diamide | |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of resistance to quinones and diamide | ||
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| + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU13670 mhqR] | ||
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 16 kDa, 6.42 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 16 kDa, 6.42 | ||
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[kinD]]'', ''[[motB]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[kinD]]'', ''[[motB]]'' | ||
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| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU13670 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU13670 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU13670 DNA_with_flanks] |
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|colspan="2" | '''Genetic context''' <br/> [[Image:ykvE_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:ykvE_context.gif]] | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
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| − | |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mhqR_1433199_1433636_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:mhqR_expression.png|500px]] | + | |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mhqR_1433199_1433636_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:mhqR_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU13670]] |
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=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU13670&redirect=T BSU13670] | ||
* '''DBTBS entry:''' no entry | * '''DBTBS entry:''' no entry | ||
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=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU13670&redirect=T BSU13670] | ||
* '''Structure:''' | * '''Structure:''' | ||
Latest revision as of 13:33, 2 April 2014
- Description: MarR-family transcriptional repressor of azoR2, mhqA, mhqD-mhqE and mhqN-mhqO-mhqP expression
| Gene name | mhqR |
| Synonyms | ykvE |
| Essential | no |
| Product | MarR-family transcriptional repressor |
| Function | regulation of resistance to quinones and diamide |
| Gene expression levels in SubtiExpress: mhqR | |
| MW, pI | 16 kDa, 6.42 |
| Gene length, protein length | 435 bp, 145 aa |
| Immediate neighbours | kinD, motB |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
transcription factors and their control, resistance against oxidative and electrophile stress
This gene is a member of the following regulons
The MhqR regulon
The gene
Basic information
- Locus tag: BSU13670
Phenotypes of a mutant
- resistant to quinones and diamide
Database entries
- BsubCyc: BSU13670
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- BsubCyc: BSU13670
- Structure:
- UniProt: O31672
- KEGG entry: [2]
- E.C. number:
Additional information
- Binding site: tATCTcgaAtTCgAGATaaaa PubMed
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Haike Antelmann,University of Greifswald, Germany
Your additional remarks
References
Reviews
Haike Antelmann, Michael Hecker, Peter Zuber
Proteomic signatures uncover thiol-specific electrophile resistance mechanisms in Bacillus subtilis.
Expert Rev Proteomics: 2008, 5(1);77-90
[PubMed:18282125]
[WorldCat.org]
[DOI]
(I p)
Original articles
Stefanie Töwe, Montira Leelakriangsak, Kazuo Kobayashi, Nguyen Van Duy, Michael Hecker, Peter Zuber, Haike Antelmann
The MarR-type repressor MhqR (YkvE) regulates multiple dioxygenases/glyoxalases and an azoreductase which confer resistance to 2-methylhydroquinone and catechol in Bacillus subtilis.
Mol Microbiol: 2007, 66(1);40-54
[PubMed:17725564]
[WorldCat.org]
[DOI]
(P p)
