treP

treP
168

trehalose permease of the phosphotransferase system, EIIBC of the PTS

Locus
BSU_07800
Molecular weight
49.84 kDa
Isoelectric point
8.56
Protein length
Gene length
Function
trehalose uptake and phosphorylation
Product
trehalose-specific PTS permease, EIIBC component
Essential
no
E.C.
2.7.1.69
Synonyms
treP, treB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1264 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
850,367 → 851,779
The protein
Catalyzed reaction/ biological activity
α,α-trehalose + Nπ-phospho-L-histidyl-[protein] --> α,α-trehalose 6-phosphate + L-histidyl-[protein] (according to UniProt)
Protein family
PTS permease, sucrose family PubMed
PTS EIIB domain type-1 (aa 1-88) (according to UniProt)
PTS EIIC domain type-1 (aa 108-470) (according to UniProt)
Structure
2IPJ (PDB) (from Clostridium difficile, the PTS EIIB domain, 41.4% identity) PubMed
Paralogous protein(s)
cell membrane (according to UniProt)
Expression and Regulation
Operons
Description
Regulation
expressed under conditions of phosphate limitation (PhoP) PubMed
Regulatory mechanism
TreR: repression, PubMed, in treR regulon
CcpA: repression, PubMed, in ccpA regulon
PhoP: activation, PubMed, in phoP regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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trePtreR

2024-12-22 06:02:44

ghost

87

5ea0c439875fc22b9a05971658c7c0a460d25052

9C91E3C2B12C6666EE92EE6C971F82C82DDCB383

Biological materials
Mutant
MGNA-C259 (treP::erm), available at the NBRP B. subtilis, Japan
BKE07800 (ΔtreP::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATGCCAACCCCTCCGTATC,  downstream forward: _UP4_TAACAAGTGGGGAGCGGGAC
BKK07800 (ΔtreP::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATGCCAACCCCTCCGTATC,  downstream forward: _UP4_TAACAAGTGGGGAGCGGGAC
References
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BC568649A341B2E6341993EDA4BF52BDE18A3294

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Time of last update: 2025-01-06 09:01:16

Author of last update: Jstuelk