Difference between revisions of "FadH"

From SubtiWiki
Jump to: navigation, search
(→‎Extended information on the protein)
 
(9 intermediate revisions by 2 users not shown)
Line 14: Line 14:
 
|style="background:#ABCDEF;" align="center"|'''Function''' || fatty acid degradation
 
|style="background:#ABCDEF;" align="center"|'''Function''' || fatty acid degradation
 
|-
 
|-
−
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/fatty_acid_deg.html Fatty acid degradation]'''
+
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU14060 fadH]
 +
|-
 +
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=fadH fadH]'''
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 26 kDa, 6.495   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 26 kDa, 6.495   
Line 22: Line 24:
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ykuE]]'', ''[[fadG]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ykuE]]'', ''[[fadG]]''
 
|-
 
|-
−
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB13279&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
+
|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU14060 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU14060 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU14060 DNA_with_flanks]
 
|-
 
|-
 
|colspan="2" | '''Genetic context''' <br/> [[Image:ykuF_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:ykuF_context.gif]]
 
  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
 
  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
 +
|-
 +
|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=fadH_1478072_1478836_1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:fadH_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU14060]]
 
|-
 
|-
 
|}
 
|}
  
 
__TOC__
 
__TOC__
 +
<br/><br/><br/><br/>
 +
<br/><br/><br/><br/>
 +
<br/><br/><br/><br/>
 +
<br/><br/><br/><br/>
 +
<br/><br/><br/><br/>
 +
  
 
<br/><br/><br/><br/><br/><br/>
 
<br/><br/><br/><br/><br/><br/>
Line 48: Line 58:
  
 
=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU14060&redirect=T BSU14060]
  
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ykuFG.html]
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ykuFG.html]
Line 85: Line 96:
  
 
=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU14060&redirect=T BSU14060]
  
 
* '''Structure:'''
 
* '''Structure:'''
Line 100: Line 112:
 
* '''Operon:''' ''[[fadH]]-[[fadG]]'' {{PubMed|17189250}}  
 
* '''Operon:''' ''[[fadH]]-[[fadG]]'' {{PubMed|17189250}}  
  
−
* '''[[Sigma factor]]:'''  
+
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=fadH_1478072_1478836_1 fadH] {{PubMed|22383849}}
 +
 
 +
* '''Sigma factor:'''  
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
Line 108: Line 122:
 
** [[FadR]]: transcription repression {{PubMed|17189250}}  
 
** [[FadR]]: transcription repression {{PubMed|17189250}}  
  
−
* '''Additional information:'''  
+
* '''Additional information:'''
  
 
=Biological materials =
 
=Biological materials =

Latest revision as of 13:34, 2 April 2014

  • Description: 2,4-dienoyl-CoA reductase

Gene name fadH
Synonyms ykuF
Essential no
Product 2,4-dienoyl-CoA reductase
Function fatty acid degradation
Gene expression levels in SubtiExpress: fadH
Metabolic function and regulation of this protein in SubtiPathways:
fadH
MW, pI 26 kDa, 6.495
Gene length, protein length 762 bp, 254 aa
Immediate neighbours ykuE, fadG
Sequences Protein DNA DNA_with_flanks
Genetic context
YkuF context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
FadH expression.png




























Categories containing this gene/protein

utilization of lipids

This gene is a member of the following regulons

FadR regulon

The gene

Basic information

  • Locus tag: BSU14060

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH (according to Swiss-Prot)
  • Protein family: 2,4-dienoyl-CoA reductase subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
    • induced in the presence of long-chain fatty acids (FadR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Yasutaro Fujita, Hiroshi Matsuoka, Kazutake Hirooka
Regulation of fatty acid metabolism in bacteria.
Mol Microbiol: 2007, 66(4);829-39
[PubMed:17919287] [WorldCat.org] [DOI] (P p)

Hiroshi Matsuoka, Kazutake Hirooka, Yasutaro Fujita
Organization and function of the YsiA regulon of Bacillus subtilis involved in fatty acid degradation.
J Biol Chem: 2007, 282(8);5180-94
[PubMed:17189250] [WorldCat.org] [DOI] (P p)

Retrieved from "http://subtiwiki-test.uni-goettingen.de/wiki//index.php?title=FadH&oldid=199761"