Difference between revisions of "FsrA"
(→Extended information on the RNA) |
|||
| (8 intermediate revisions by 3 users not shown) | |||
| Line 30: | Line 30: | ||
= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
{{SubtiWiki category|[[carbon core metabolism]]}}, | {{SubtiWiki category|[[carbon core metabolism]]}}, | ||
| + | {{SubtiWiki category|[[acquisition of iron]]}}, | ||
{{SubtiWiki category|[[ncRNA]]}} | {{SubtiWiki category|[[ncRNA]]}} | ||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
{{SubtiWiki regulon|[[Fur regulon]]}} | {{SubtiWiki regulon|[[Fur regulon]]}} | ||
| − | =The [[FsrA regulon | + | =The [[FsrA regulon]]''= |
| + | |||
=The gene= | =The gene= | ||
| Line 42: | Line 44: | ||
===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| + | * transcription profile of a ''[[fsrA]]'' mutant strain: [http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE27416 GEO] {{PubMed|22389480}} | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=?&redirect=T ?] | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=?&redirect=T ?] | ||
* '''DBTBS entry:''' no entry | * '''DBTBS entry:''' no entry | ||
| Line 49: | Line 54: | ||
* '''SubtiList entry:''' no entry | * '''SubtiList entry:''' no entry | ||
| − | * '''Structure:''' | + | * '''GEO entry:''' [http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE27416 GEO] {{PubMed|22389480}} |
| + | |||
| + | * '''Structure:''' | ||
=== Additional information=== | === Additional information=== | ||
| Line 67: | Line 74: | ||
=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' hybridizes to ''[[sdhC]], [[citB]], [[lutB]], and [[leuC]]-[[leuD]]'' mRNAs and inhibits their translation. | + | * '''Catalyzed reaction/ biological activity:''' hybridizes to ''[[sdhC]], [[citB]], [[lutB]], [[gltA]]-[[gltB]]'', and ''[[leuC]]-[[leuD]]'' mRNAs and inhibits their translation. {{PubMed|18697947,22389480}} |
=== Extended information on the RNA=== | === Extended information on the RNA=== | ||
| Line 74: | Line 81: | ||
* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| − | ** Binds ''[[sdhC]], [[citB]], [[lutB]], and [[leuC]]-[[leuD]]'' mRNAs | + | ** Binds ''[[sdhC]], [[citB]], [[lutB]], [[gltA]]-[[gltB]]'', and ''[[leuC]]-[[leuD]]'' mRNAs {{PubMed|18697947,22389480}} |
* '''[[Localization]]''' | * '''[[Localization]]''' | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=?&redirect=T ?] | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=?&redirect=T ?] | ||
* '''Structure''': | * '''Structure''': | ||
| Line 112: | Line 121: | ||
=References= | =References= | ||
| − | <pubmed>18697947, </pubmed> | + | <pubmed>22427629,18697947,22389480</pubmed> |
[[Category:small RNA]] | [[Category:small RNA]] | ||
Latest revision as of 15:23, 2 April 2014
- Description: regulatory RNA
| Gene name | fsrA |
| Synonyms | |
| Essential | no |
| Product | sRNA FsrA |
| Function | inhibition of sdhC translation |
| Gene length | aaa bp |
| Immediate neighbours | ykuI, ykuJ |
| Gene sequence (+200bp) | |
Genetic context 
| |
Contents
Categories containing this gene/protein
carbon core metabolism, acquisition of iron, ncRNA
This gene is a member of the following regulons
The FsrA regulon
The gene
Basic information
- Locus tag:
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: no entry
- Structure:
Additional information
- Swiss prot entry:
- KEGG entry: no entry
- E.C. number:
Additional information
The RNA
Basic information/ Evolution
- Catalyzed reaction/ biological activity: hybridizes to sdhC, citB, lutB, gltA-gltB, and leuC-leuD mRNAs and inhibits their translation. PubMed
Extended information on the RNA
- Kinetic information
Database entries
- Structure:
Additional information
Expression and regulation
- Operon:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
Labs working on this gene/RNA
John Helmann, Cornell University, USA Homepage
Your additional remarks
References
Gregory T Smaldone, Haike Antelmann, Ahmed Gaballa, John D Helmann
The FsrA sRNA and FbpB protein mediate the iron-dependent induction of the Bacillus subtilis lutABC iron-sulfur-containing oxidases.
J Bacteriol: 2012, 194(10);2586-93
[PubMed:22427629]
[WorldCat.org]
[DOI]
(I p)
Gregory T Smaldone, Olga Revelles, Ahmed Gaballa, Uwe Sauer, Haike Antelmann, John D Helmann
A global investigation of the Bacillus subtilis iron-sparing response identifies major changes in metabolism.
J Bacteriol: 2012, 194(10);2594-605
[PubMed:22389480]
[WorldCat.org]
[DOI]
(I p)
Ahmed Gaballa, Haike Antelmann, Claudio Aguilar, Sukhjit K Khakh, Kyung-Bok Song, Gregory T Smaldone, John D Helmann
The Bacillus subtilis iron-sparing response is mediated by a Fur-regulated small RNA and three small, basic proteins.
Proc Natl Acad Sci U S A: 2008, 105(33);11927-32
[PubMed:18697947]
[WorldCat.org]
[DOI]
(I p)
