Difference between revisions of "Two-component systems"

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** [[NatK]], [[NatR]]
 
** [[NatK]], [[NatR]]
 
** [[PhoR]], [[PhoP]]
 
** [[PhoR]], [[PhoP]]
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** [[PsdS]], [[PsdR]]
 
** [[ResE]], [[ResD]]
 
** [[ResE]], [[ResD]]
 
** [[WalK]], [[WalR]]: the only essential two-component system!
 
** [[WalK]], [[WalR]]: the only essential two-component system!
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** [[YkoH]], [[YkoG]]
 
** [[YkoH]], [[YkoG]]
 
** [[YrkQ]], [[YrkP]]
 
** [[YrkQ]], [[YrkP]]
** [[YvcQ]], [[YvcP]]
 
 
** [[YvrG]], [[YvrHb]]
 
** [[YvrG]], [[YvrHb]]
 
** [[YxdK]], [[YxdJ]]
 
** [[YxdK]], [[YxdJ]]
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* [[phosphoproteins]]
 
* [[phosphoproteins]]
 
* [[protein kinases and phosphatases]]
 
* [[protein kinases and phosphatases]]
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 +
==Important original publications==
 +
<pubmed>21665979</pubmed>
  
 
==Reviews==
 
==Reviews==
<pubmed>17338439 19575571 11406410 10966457 10932244 17158704 10094672 11489844 1664534 17433693 10745001 17913492 18832064 19943903 20117042 18076326 20080056 20133181 20133179 21051349 </pubmed>
+
<pubmed>17338439 19575571 17158704 17433693  17913492 18832064 19943903 20117042 18076326 20080056 20133181 20133179 21051349 23279101 23352354 22746333 24494032    27519796</pubmed>
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'''Reviews that appeared before 2005''': {{PubMed|11406410,10966457,10932244,10094672,11489844,10745001,1664534}}

Latest revision as of 08:05, 25 August 2016

Two component systems are signal transduction systems that consist of a sensor kinase and a response regulator (usually a transcription factor). The kinase autophosphorylates on a His residue (more preciely, one subunit of the dimeric kinase phosphorylates the His residue of the other subunit), and the phosphate group can then be transferred to an aspartate residue in the cognate response regulator. Some response regulators can also autophosphorylate using acety-phosphate as the phosphate donor. More complex signal transduction systems of this class are called phosphorelay. The paradigm for a phosphorelay is the pathway leading to the phosphorylation of Spo0A.

Two-component systems in B. subtilis (kinase, regulator)

  • Orphan response regulator

The phosphorelay

  • The ultimate target

Related lists

Important original publications


Reviews

Reviews that appeared before 2005: PubMed