pcrB

pcrB
168

heptaprenylglyceryl phosphate synthase

Locus
BSU_06600
Molecular weight
24.94 kDa
Isoelectric point
4.2
Protein length
228 aaSequenceBlast
Gene length
687 bpSequenceBlast
Function
unknown
Product
heptaprenylglyceryl phosphate synthase
Essential
no
Synonyms
pcrB, yerE
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1646 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
718,622  719,308
The protein
Catalyzed reaction/ biological activity
production of heptaprenylglyceryl phosphate from heptaprenyl diphosphate and glycerol-1-phosphate PubMed
all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate --> 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate (according to UniProt)
Protein family
GGGP/HepGP synthase family (single member, according to UniProt)
Structure
1VIZ (PDB) PubMed
O34790 (AlphaFold)
Expression and Regulation
Operons
Genes
pcrB-pcrA-ligA-yerH
Description
PubMed
Regulation
induced by DNA damage (LexA) PubMed
Regulatory mechanism
LexA: repression, PubMed, in lexA regulon
Open in new tab

pcrB→yerH

2025-04-10 00:10:33

ghost

142

dec907ab37dccb52bc69c4b0f73a394d7c7ee297

FEC0EF466BE2820083D3AF39105152A266EEF005

Biological materials
Mutant
MGNA-A926 (yerE::erm), available at the NBRP B. subtilis, Japan
BKE06600 (pcrB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACGTCATACGTTCCTCCAT,  downstream forward: _UP4_TAGTAAATTGTACGGATTTG
BKK06600 (pcrB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACGTCATACGTTCCTCCAT,  downstream forward: _UP4_TAGTAAATTGTACGGATTTG
References
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0BA7EC658F5C2397A90B68AC234D04966966561C

Page visits: 3954

Time of last update: 2025-04-12 06:58:22

Author of last update: Melvin.boenninger