Difference between revisions of "Fur"

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* '''Regulation:''' repressed by [[PerR]]
 
* '''Regulation:''' repressed by [[PerR]]
 +
** repressed in the absence of hydrogen peroxide ([[PerR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12029044 PubMed]
  
 
* '''Regulatory mechanism:''' [[PerR]]: transcription repression
 
* '''Regulatory mechanism:''' [[PerR]]: transcription repression
 +
** [[PerR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12029044 PubMed]
  
 
* '''Additional information:'''
 
* '''Additional information:'''

Revision as of 16:57, 11 June 2009

  • Description: transcription regulator of iron homoeostasis

Gene name fur
Synonyms yqkL
Essential no
Product transcriptional repressor
Function regulation of iron homoeostasis

and transcription of ferri-siderophore uptake genes

MW, pI 17 kDa, 5.374
Gene length, protein length 447 bp, 149 aa
Immediate neighbours ripX, spoIIM
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Fur context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU23520

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: Fur family (according to Swiss-Prot)

Genes controlled by Fur

fsrA

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: fur
  • Regulation: repressed by PerR
    • repressed in the absence of hydrogen peroxide (PerR) PubMed
  • Regulatory mechanism: PerR: transcription repression
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

Your additional remarks

References

  1. Baichoo N, Wang T, Ye R, Helmann JD. (2002) Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon. Mol Microbiol. Sep;45(6): 1613-29. PubMed
  2. Ollinger J, Song KB, Antelmann H, Hecker M, Helmann JD. (2006) Role of the Fur regulon in iron transport in Bacillus subtilis. J Bacteriol. May;188(10): 3664-73. PubMed
  3. Gaballa A, Antelmann H, Aguilar C, Khakh SK, Song KB, Smaldone GT, Helmann JD (2008) The Bacillus subtilis iron-sparing response is mediated by a Fur-regulated small RNA and three small, basic proteins. PNAS 105: 11927-11932. PubMed