Difference between revisions of "LexA"
Line 93: | Line 93: | ||
* '''Regulation:''' autoregulation by LexA [http://www.ncbi.nlm.nih.gov/sites/entrez/16267290 PubMed] | * '''Regulation:''' autoregulation by LexA [http://www.ncbi.nlm.nih.gov/sites/entrez/16267290 PubMed] | ||
+ | ** repressed when no DNA damage is present ([[LexA]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8899710 PubMed] | ||
* '''Regulatory mechanism:''' autorepression | * '''Regulatory mechanism:''' autorepression | ||
+ | ** [[LexA]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/8899710 PubMed] | ||
* '''Additional information:''' | * '''Additional information:''' |
Revision as of 16:51, 11 June 2009
- Description: transcriptional repressor of the SOS regulon
Gene name | lexA |
Synonyms | dinR |
Essential | no |
Product | transcriptional repressor of the SOS regulon |
Function | regulation of DNA damage repair |
MW, pI | 22 kDa, 5.155 |
Gene length, protein length | 615 bp, 205 aa |
Immediate neighbours | fosB, yneA |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
|
Contents
The gene
Basic information
- Locus tag: BSU17850
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Represses dinA, dinB, dinC, recA genes and itself by binding to the 14 bp palindromic sequence 5'-CGAACNNNNGTTCG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (according to Swiss-Prot)
- Protein family: peptidase S24 family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- Swiss prot entry: P31080
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: lexA
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
- Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed