Difference between revisions of "PurE"
(→Expression and regulation) |
|||
Line 92: | Line 92: | ||
* '''[[Sigma factor]]:''' [[SigA]] | * '''[[Sigma factor]]:''' [[SigA]] | ||
− | * '''Regulation:''' | + | * '''Regulation:''' |
+ | ** repressed in the presence of adenine or adenosine([[PurR]]) | ||
+ | ** repressed in the presence of guanine([[G-box]]) | ||
− | * '''Regulatory mechanism:''' [[PurR]]: transcription repression (molecular inducer: PRPP) | + | * '''Regulatory mechanism:''' |
+ | ** [[PurR]]: transcription repression (molecular inducer: PRPP) | ||
+ | ** [[G-box]]: transcription termination/ antitermination ([[riboswitch]]) | ||
* '''Additional information:''' | * '''Additional information:''' |
Revision as of 19:36, 31 May 2009
- Description: phosphoribosylaminoimidazole carboxylase (ATP-dependent)
Gene name | purE |
Synonyms | |
Essential | no |
Product | phosphoribosylaminoimidazole carboxylase (ATP-dependent) |
Function | purine biosynthesis |
MW, pI | 17 kDa, 5.199 |
Gene length, protein length | 486 bp, 162 aa |
Immediate neighbours | yebG, purK |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
|
Contents
The gene
Basic information
- Coordinates:
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2 (according to Swiss-Prot)
- Protein family: AIR carboxylase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- Swiss prot entry: P12044
- KEGG entry: BSU06420
- E.C. number: 4.1.1.21
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- PurR: transcription repression (molecular inducer: PRPP)
- G-box: transcription termination/ antitermination (riboswitch)
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
- Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed