Difference between revisions of "GyrA"
(→Basic information/ Evolution) |
|||
| Line 1: | Line 1: | ||
| − | * '''Description:''' | + | * '''Description:''' DNA-Gyrase (subunit A) <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
| Line 10: | Line 10: | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed] | |style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed] | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || DNA | + | |style="background:#ABCDEF;" align="center"| '''Product''' || DNA-Gyrase (subunit A) |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || initation of replication cycle and DNA elongation | + | |style="background:#ABCDEF;" align="center"|'''Function''' || DNA superrcoiling, initation of replication cycle and DNA elongation |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 91 kDa, 5.215 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 91 kDa, 5.215 | ||
Revision as of 16:36, 16 March 2009
- Description: DNA-Gyrase (subunit A)
| Gene name | gyrA |
| Synonyms | nalA |
| Essential | yes PubMed |
| Product | DNA-Gyrase (subunit A) |
| Function | DNA superrcoiling, initation of replication cycle and DNA elongation |
| MW, pI | 91 kDa, 5.215 |
| Gene length, protein length | 2463 bp, 821 aa |
| Immediate neighbours | gyrB, rrnO-16S |
| Gene sequence (+200bp) | Protein sequence |
Genetic context 
| |
Contents
The gene
Basic information
- Coordinates:
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s): ParC
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions: GyrA-GyrB
- Localization: nucleoid-associated in actively growing cells PubMed
Database entries
- Structure:
- Swiss prot entry:
- KEGG entry:
- E.C. number:
Additional information
Expression and regulation
- Operon: gyrA PubMed
- Regulation:
- Regulatory mechanism:
- Additional information: GyrA is subject to Clp-dependent proteolysis upon glucose starvation PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
- Huang et al. (1998) Bipolar localization of Bacillus subtilis topoisomerase IV, an enzyme required for chromosome segregation. Proc. Natl. Acad. Sci. USA 95: 4652-4657. PubMed
- Gerth et al. (2008) Clp-dependent proteolysis down-regulates central metabolic pathways in glucose-starved Bacillus subtilis. J Bacteriol 190:321-331 PubMed
- Ogasawara et al. (1985) Structure and function of the region of the replication origin of the Bacillus subtilis chromosome. IV. Transcription of the oriC region and expression of DNA gyrase genes and other open reading frames.Nucl. Acids Res. 11: 2267-2279. PubMed
