Difference between revisions of "RatA"
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| − | * '''Description:''' antisense | + | * '''Description:''' regulatory RNA, [[small RNAs|ncRNA]], antisense for ''[[txpA]]'' <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
| Line 10: | Line 10: | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || RNA | + | |style="background:#ABCDEF;" align="center"| '''Product''' || ''[[txpA]]'' [[small RNAs|antisense RNA]] |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || | + | |style="background:#ABCDEF;" align="center"|'''Function''' || control of ''[[txpA]]'' expression |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''Gene length''' || 222 bp | |style="background:#ABCDEF;" align="center"| '''Gene length''' || 222 bp | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ | + | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[txpA]]'', ''[[bsrH]]'' |
|- | |- | ||
|style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/genE_nucleotide.txt Gene sequence (+200bp) ]''' | |style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/genE_nucleotide.txt Gene sequence (+200bp) ]''' | ||
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:genE_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:genE_context.gif]] | ||
| + | |- | ||
| + | |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=S976_2678362_2678577_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:ratA_expression.png|500px]] | ||
|- | |- | ||
|} | |} | ||
| Line 28: | Line 30: | ||
<br/><br/> | <br/><br/> | ||
| + | = [[Categories]] containing this gene/protein = | ||
| + | {{SubtiWiki category|[[toxins, antitoxins and immunity against toxins]]}}, | ||
| + | {{SubtiWiki category|[[Skin element]]}}, | ||
| + | {{SubtiWiki category|[[ncRNA]]}} | ||
| + | |||
| + | = This gene is a member of the following [[regulons]] = | ||
| + | |||
| + | =The [[ratA regulon]]: ''[[txpA]]'' = | ||
=The gene= | =The gene= | ||
=== Basic information === | === Basic information === | ||
| − | * ''' | + | * '''Locus tag:''' |
===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=?&redirect=T ?] | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=?&redirect=T ?] | ||
| − | * '''DBTBS entry:''' | + | * '''DBTBS entry:''' no entry |
* '''SubtiList entry:''' | * '''SubtiList entry:''' | ||
| Line 54: | Line 66: | ||
* '''Operon:''' | * '''Operon:''' | ||
| − | * '''Sigma factor:''' | + | * '''[[Sigma factor]]:''' |
* '''Regulation:''' | * '''Regulation:''' | ||
| Line 60: | Line 72: | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| − | * '''Additional information:''' | + | * '''Additional information:''' |
| + | ** the ''[[txpA]]'' mRNA-''[[RatA]]'' RNA duplex is degraded by [[rnc|RNase III]] {{PubMed|23300471}} | ||
=Biological materials = | =Biological materials = | ||
| Line 78: | Line 91: | ||
=Labs working on this gene/protein= | =Labs working on this gene/protein= | ||
| − | [[Richard Losick]], Harvard University, Cambridge, USA | + | [[Richard Losick]], Harvard University, Cambridge, USA [http://www.mcb.harvard.edu/Losick/ Homepage] |
=Your additional remarks= | =Your additional remarks= | ||
=References= | =References= | ||
| + | ==Reviews== | ||
| + | <pubmed> 23300472 </pubmed> | ||
| + | |||
| + | ==Original publications== | ||
| + | <pubmed>16166525, 23300471</pubmed> | ||
| − | + | [[Category:small RNA]] | |
| − | |||
Latest revision as of 12:06, 28 January 2017
| Gene name | ratA |
| Synonyms | |
| Essential | no |
| Product | txpA antisense RNA |
| Function | control of txpA expression |
| Gene length | 222 bp |
| Immediate neighbours | txpA, bsrH |
| Gene sequence (+200bp) | |
| Genetic context File:GenE context.gif | |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
toxins, antitoxins and immunity against toxins, Skin element, ncRNA
This gene is a member of the following regulons
The ratA regulon: txpA
The gene
Basic information
- Locus tag:
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry:
- Structure:
Additional information
The RNA
binds the txpA mRNA and triggers its degradation PubMed
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Richard Losick, Harvard University, Cambridge, USA Homepage
Your additional remarks
References
Reviews
Fabian M Commichau, Jörg Stülke
A mystery unraveled: essentiality of RNase III in Bacillus subtilis is caused by resident prophages.
PLoS Genet: 2012, 8(12);e1003199
[PubMed:23300472]
[WorldCat.org]
[DOI]
(I p)
Original publications
Sylvain Durand, Laetitia Gilet, Ciarán Condon
The essential function of B. subtilis RNase III is to silence foreign toxin genes.
PLoS Genet: 2012, 8(12);e1003181
[PubMed:23300471]
[WorldCat.org]
[DOI]
(I p)
Jessica M Silvaggi, John B Perkins, Richard Losick
Small untranslated RNA antitoxin in Bacillus subtilis.
J Bacteriol: 2005, 187(19);6641-50
[PubMed:16166525]
[WorldCat.org]
[DOI]
(P p)
