acoR

acoR
168

transcriptional activator of the acoA-acoB-acoC-acoL operon

Locus
BSU_08100
Molecular weight
66.98 kDa
Isoelectric point
7.88
Protein length
605 aaSequenceBlast
Gene length
1818 bpSequenceBlast
Function
regulation of acetoin utilization
Product
transcriptional activator (for SigL-dependent promoter)
Essential
no
Synonyms
acoR, yfjG, yzcB
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG3284 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
883,758  885,575
The protein
Protein family
Transcription factors activating transcription at SigL-dependent promoters
Domains
Sigma-54 factor interaction domain (aa 295-520) (according to UniProt)
Structure
5EXX (PDB) (from Pseudomonas aeruginosa, C-terminal doamin, corresponds to aa 292 ... 598, 43% identity) PubMed
O31551 (AlphaFold)
Expression and Regulation
Operons
Genes
acoR-sspH
Description
PubMed
Regulation
repressed by glucose (3.7-fold) (CcpA) PubMed
Regulatory mechanism
CcpA: repression, PubMed, in ccpA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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acoR→sspH

2025-03-15 18:32:39

ghost

96

f16cdf322895e99766a36c4df321103c1bdd5ee5

FD8E94B07C9DDF75DB8610CDEEF8B8C90FF67E80

Biological materials
Mutant
MGNA-C352 (acoR::erm), available at the NBRP B. subtilis, Japan
1A912 ( acoR::kan), PubMed, available at BGSC and in Jörg Stülke's lab
BKE08100 (acoR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTCCTTGATCGCTCCTC,  downstream forward: _UP4_TAAAGCATACTTCCTTCAGG
BKK08100 (acoR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTCCTTGATCGCTCCTC,  downstream forward: _UP4_TAAAGCATACTTCCTTCAGG
Labs working on this gene/protein
Michel Debarbouille, Pasteur Institute, Paris, France Homepage
References
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706864AAF36684AD5E46F30E9EB76315AB412700

Page visits: 6714

Time of last update: 2025-04-10 01:33:53

Author of last update: Melvin.boenninger