hbs
168
non-specific DNA-binding protein Hbsu
Locus
BSU_22790
Molecular weight
9.75 kDa
Isoelectric point
9.5
Function
DNA packaging, regulation of nucleoid compaction, required for the initiation of DNA replication
Product
non-specific DNA-binding protein Hbsu
Essential
yes
Synonyms
hbs, dbpA, hupA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0776 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
The protein
Catalyzed reaction/ biological activity
binds to curved DNA without apparent sequence specificity PubMed
binds to abasic DNA lesions PubMed
condenses the bacterial chromosome PubMed
plays an essential role in the initiation of DNA replication, likely acting to promote origin melting by DnaA, but also has a second DnaA-independent essential function PubMed
Protein family
bacterial histone-like protein family (with YonN, according to UniProt)
Structure
1HUU (PDB) (Geobacillus stearothermophilus) PubMed
Modification
phosphorylated on Arg-61 PubMed
phosphorylation on Thr-4 PubMed
can be acetylated on Lys-3, Lys-18, Lys-37, Lys-41, Lys-75, Lys-80, and Lys-86 PubMed
Effectors of protein activity
Paralogous protein(s)
uniformly associated with the nucleoid in vegetative cells and forespores PubMed
Expression and Regulation
Operons
Genes
Description
Regulation
Regulatory mechanism
Sigma factors
Additional information
Hbs is present with about 50,000 copies per genome in vegetative cells and spores, it is one of the most abundant proteins in B. subtilis PubMed
Biological materials
Two-hybrid system
B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Fabian Commichau's lab
Labs working on this gene/protein
Ciaran Condon, IBPC, Paris, France Homepage
David Dubnau,Rutgers University, Newark, USA
References
Reviews
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Original Publications
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Time of last update: 2025-04-04 00:24:43
Author of last update: Jstuelk