TatAY

• Description: component of the TatAY-TatCY twin-arginine translocase
  
  

Gene name	tatAY
Synonyms	ydiI
Essential	no
Product	component of the twin-arginine translocation pathway
Function	TAT protein secretion
Gene expression levels in SubtiExpress: tatAY
Interactions involving this protein in SubtInteract: TatAY
Metabolic function and regulation of this protein in SubtiPathways: TatAY
MW, pI	5 kDa, 6.558
Gene length, protein length	171 bp, 57 aa
Immediate neighbours	rex, tatCY
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

protein secretion, membrane proteins

The gene

Basic information

• Locus tag: BSU05980

Database entries

• BsubCyc: BSU05980

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • secretion of EfeB and of YkuE
  • delivers QcrA to the membrane PubMed

• Protein family: tatA/E family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:
  • TatAY-TatCY PubMed
  • WprA-TatAY PubMed
  • TatAY-TatAD PubMed
  • TatAC-TatAY PubMed

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• BsubCyc: BSU05980

• Structure:

• UniProt: O05522

• KEGG entry: [2]

• E.C. number:

Additional information

• TatAY-TatCY-dependent export of YkuE and YwbN requires a functional WprA PubMed

Expression and regulation

• Operon:
  • ydiG-rex-tatAY-tatCY PubMed
  • tatAY-tatCY PubMed

• Expression browser: tatAY PubMed

• Sigma factor:

• Regulation: constitutitvely expressed PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Kenneth Cline
Mechanistic Aspects of Folded Protein Transport by the Twin Arginine Translocase (Tat).
J Biol Chem: 2015, 290(27);16530-8
[PubMed:25975269] [WorldCat.org] [DOI] (I p)

Vivianne J Goosens, Carmine G Monteferrante, Jan Maarten van Dijl
The Tat system of Gram-positive bacteria.
Biochim Biophys Acta: 2014, 1843(8);1698-706
[PubMed:24140208] [WorldCat.org] [DOI] (P p)

Tracy Palmer, Ben C Berks
The twin-arginine translocation (Tat) protein export pathway.
Nat Rev Microbiol: 2012, 10(7);483-96
[PubMed:22683878] [WorldCat.org] [DOI] (I e)