gamR

gamR
168

transcriptional repressor (GntR family) of the gamA-gamP operon

Locus
BSU_02370
Molecular weight
26.45 kDa
Isoelectric point
5.56
Protein length
235 aaSequenceBlast
Gene length
708 bpSequenceBlast
Function
regulation of glucosamine utilization
Product
transcriptional regulator (GntR family)
Essential
no
Synonyms
gamR, ybgA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2188 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
257,791 → 258,498
The protein
Protein family
GntR family of transcription factors
Domains
HTH gntR-type domain (aa 2-70) (according to UniProt)
Structure
2WV0 (PDB) (NagR, 34% identity) PubMed
O31459 (AlphaFold)
Effectors of protein activity
glucosamine-6-phosphate acts as molecular inducer that prevents GamR from binding to its operator sites in the promoter regions of the gamA-gamP and gamR-ybgB  operons PubMed
Paralogous protein(s)
NagR, YydK, GmuR, FrlR, TreR, YmfC
Expression and Regulation
Operons
Genes
gamR-ybgB
Description
PubMed
Regulation
induced by glucosamine (gamR) PubMed
induced by glucosamine (GamR) PubMed
Regulatory mechanism
GamR: repression, PubMed, in gamR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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gamR→ybgB

2025-04-07 07:31:07

ghost

93

23ad24e5d0f0ebe864f8ce62d459ff58ea2562d9

E34905CD5A79F10FB8D4BF3FBA89AF47E5096F33

Biological materials
Mutant
BKE02370 (ΔgamR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTCATTCTCCCCATTCT,  downstream forward: _UP4_TAAAGCAATGTGTTTTAAGA
BKK02370 (ΔgamR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTCATTCTCCCCATTCT,  downstream forward: _UP4_TAAAGCAATGTGTTTTAAGA
References
Reviews
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Original Publications
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FB074E8CFCA1C0198457170A7AFD85C875B34DF2

Page visits: 3745

Time of last update: 2025-04-10 01:11:50

Author of last update: Melvin.boenninger